Vits Sabine, Dissemond Joachim, Schadendorf Dirk, Kriegler Lisa, Körber Andreas, Schedlowski Manfred, Cesko Elvir
Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Essen, Germany.
Department of Dermatology, Venereology and Allergology, University Hospital Essen, Essen, Germany.
Int Wound J. 2015 Dec;12(6):664-8. doi: 10.1111/iwj.12193. Epub 2013 Dec 30.
Placebo responses have been shown to affect the symptomatology of skin diseases. However, expectation-induced placebo effects on wound healing processes have not been investigated yet. We analysed whether subjects' expectation of receiving an active drug accelerates the healing process of experimentally induced wounds. In 22 healthy men (experimental group, n = 11; control group, n = 11) wounds were induced by ablative laser on both thighs. Using a deceptive paradigm, participants in the experimental group were informed that an innovative 'wound gel' was applied on one of the two wounds, whereas a 'non-active gel' was applied on the wound of the other thigh. In fact, both gels were identical hydrogels without any active components. A control group was informed to receive a non-active gel on both wounds. Progress in wound healing was documented via planimetry on days 1, 4 and 7 after wound induction. From day 9 onwards wound inspections were performed daily accompanied by a change of the dressing and a new application of the gel. No significant differences could be observed with regard to duration or process of wound healing, either by intraindividual or by interindividual comparisons. These data document no expectation-induced placebo effect on the healing process of experimentally induced wounds in healthy volunteers.
安慰剂反应已被证明会影响皮肤病的症状。然而，期望诱导的安慰剂效应在伤口愈合过程中的作用尚未得到研究。我们分析了受试者对接受活性药物的期望是否会加速实验性诱导伤口的愈合过程。在22名健康男性中（实验组，n = 11；对照组，n = 11），通过烧蚀激光在双侧大腿诱导伤口。采用欺骗性范式，实验组的参与者被告知在两个伤口中的一个上涂抹了一种创新的“伤口凝胶”，而在另一条大腿的伤口上涂抹了“无活性凝胶”。实际上，两种凝胶都是不含任何活性成分的相同水凝胶。对照组被告知在两个伤口上都涂抹无活性凝胶。在伤口诱导后的第1、4和7天，通过平面测量记录伤口愈合进展。从第9天起，每天进行伤口检查，同时更换敷料并重新涂抹凝胶。无论是个体内比较还是个体间比较，在伤口愈合的持续时间或过程方面均未观察到显著差异。这些数据表明，在健康志愿者中，期望诱导的安慰剂效应不会对实验性诱导伤口的愈合过程产生影响。
