骆驼奶对自闭症儿童胸腺和活化调节趋化因子的影响：双盲研究。
Effect of camel milk on thymus and activation-regulated chemokine in autistic children: double-blind study.
作者信息
Bashir Shahid, Al-Ayadhi Laila Y
机构信息
1] Department of Physiology, Autism Research and Treatment Center, Shaik AL-Amodi Autism Research Chair, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia [2] Division of Cognitive Neurology, Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Department of Physiology, Autism Research and Treatment Center, Shaik AL-Amodi Autism Research Chair, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.
出版信息
Pediatr Res. 2014 Apr;75(4):559-63. doi: 10.1038/pr.2013.248. Epub 2013 Dec 27.
BACKGROUND
This study aimed to investigate the role of the effectiveness of camel milk (CM) (raw and boiled) on thymus and activation-regulated chemokine (TARC) serum levels and childhood autism rating scale (CARS) score in subjects with autism and compared to placebo group (cow milk).
METHODS
Forty-five subjects diagnosed with autism were randomly assigned to receive boiled CM for group I (n = 15), raw CM for group II (n = 15), and placebo for group III (n = 15) for 2 wk. Measures included changes in professionally completed CARS score and blood samples for TARC serum level were taken before and after milk consumption of 500 ml per day in children's regular daily diet.
RESULTS
The serum levels of TARC decreased significantly (P = 0.004) in boiled CM and in raw CM group (P = 0.01) too, but no effect was observed (P = 0.68) in placebo group. Furthermore, significant improvements were observed in CARS score (P = 0.04) in raw CM group only. There were no significant relationships between the serum of TARC level and the CARS score, age, or gender for any group.
CONCLUSION
CM administered for 2 wk significantly improved clinical measurements of autism severity and decreased serum level of TARC in autistic children, but subsequent studies are recommended.
背景
本研究旨在调查骆驼奶（生奶和煮过的奶）对自闭症患者胸腺和活化调节趋化因子（TARC）血清水平以及儿童自闭症评定量表（CARS）评分的作用，并与安慰剂组（牛奶）进行比较。
方法
45名被诊断为自闭症的受试者被随机分为三组，第一组（n = 15）接受煮过的骆驼奶，第二组（n = 15）接受生骆驼奶，第三组（n = 15）接受安慰剂，为期2周。测量指标包括专业完成的CARS评分变化，以及在儿童日常饮食中每天饮用500毫升奶前后采集的用于检测TARC血清水平的血样。
结果
煮过的骆驼奶组和生骆驼奶组的TARC血清水平均显著下降（煮过的骆驼奶组P = 0.004，生骆驼奶组P = 0.01），但安慰剂组未观察到效果（P = 0.68）。此外，仅生骆驼奶组的CARS评分有显著改善（P = 0.04）。任何组的TARC血清水平与CARS评分、年龄或性别之间均无显著关系。
结论
给予骆驼奶2周可显著改善自闭症儿童自闭症严重程度的临床测量指标，并降低其TARC血清水平，但建议进行后续研究。
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