昼夜节律钟：组织是关键。
Circadian clocks: the tissue is the issue.
机构信息
Department of Biology and Center for Biological Clocks Research, Texas A&M University, College Station, TX 77843-3258, USA.
Department of Biology and Center for Biological Clocks Research, Texas A&M University, College Station, TX 77843-3258, USA.
出版信息
Curr Biol. 2014 Jan 6;24(1):R25-R27. doi: 10.1016/j.cub.2013.11.016.
Abstract
The circadian clock uses a widely expressed pair of clock activators to drive tissue-specific rhythms in target gene expression. A new study sheds light on this tissue specificity by showing that binding of clock activators and tissue-specific transcription factors to closely associated target sites enables cooperative activation of target genes in different tissues.
摘要
生物钟利用广泛表达的一对时钟激活剂来驱动靶基因表达的组织特异性节律。一项新的研究通过表明时钟激活剂和组织特异性转录因子与密切相关的靶位点的结合能够使不同组织中的靶基因协同激活，从而揭示了这种组织特异性。
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