State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong Special Administrative Region; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region.
Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region.
J Infect. 2014 Mar;68(3):205-15. doi: 10.1016/j.jinf.2013.12.014. Epub 2014 Jan 6.
In December 2013, China reported the first human case of avian influenza A(H10N8). A 73-year-old female with chronic diseases who had visited a live poultry market succumbed with community-acquired pneumonia. While human infections with avian influenza viruses are usually associated with subtypes prevalent in poultries, A(H10N8) isolates were mostly found in migratory birds and only recently in poultries. Although not possible to predict whether this single intrusion by A(H10N8) is an accident or the start of another epidemic like the preceding A(H7N9) and A(H5N1), several features suggest that A(H10N8) is a potential threat to humans. Recombinant H10 could attach to human respiratory epithelium, and A(H10N4) virus could cause severe infections in minks and chickens. A(H10N8) viruses contain genetic markers for mammalian adaptation and virulence in the haemagglutinin (A135T, S138A[H3 numbering]), M1(N30D, T215A), NS1(P42S) and PB2(E627K) protein. Studies on this human A(H10N8) isolate will reveal its adaptability to humans. Clinicians should alert the laboratory to test for A(H5,6,7,9,10) viruses in patients with epidemiological exposure in endemic geographical areas especially when human influenza A(H1,3) and B are negative. Vigilant virological and serological surveillance for A(H10N8) in human, poultry and wild bird is important for following the trajectory of this emerging influenza virus.
2013 年 12 月，中国报告了首例人感染甲型禽流感（H10N8）病例。一名患有慢性病的 73 岁女性因社区获得性肺炎去世，她曾去过活禽市场。虽然人类感染禽流感病毒通常与家禽中流行的亚型有关，但 H10N8 分离株主要在候鸟中发现，最近才在家禽中发现。虽然无法预测 H10N8 的这次单一入侵是偶然事件还是像之前的 H7N9 和 H5N1 那样的另一次疫情的开始，但有几个特征表明 H10N8 对人类是潜在的威胁。重组 H10 可以附着在人类呼吸道上皮细胞上，H10N4 病毒可以导致水貂和鸡的严重感染。H10N8 病毒在血凝素（A135T、S138A[H3 编号]）、M1（N30D、T215A）、NS1（P42S）和 PB2（E627K）蛋白中含有适应哺乳动物和毒力的遗传标记。对这种人源 H10N8 分离株的研究将揭示其对人类的适应性。临床医生应提醒实验室在流行地区有流行病学暴露的患者中检测 A（H5、6、7、9、10）病毒，特别是当人源流感 A（H1、3）和 B 为阴性时。对人类、家禽和野生鸟类中的 H10N8 进行警惕的病毒学和血清学监测，对于跟踪这种新兴流感病毒的轨迹非常重要。
