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World J Microbiol Biotechnol. 1996 Jan;12(1):43-6. doi: 10.1007/BF00327798.
Corn-cob was used as a substrate in the production of oxytetracycline by Streptomyces rimosus TM-55 in a solidstate fermentation. Oxytetracycline was detected on day 4, and reached its maximum on day 8. Optimal conditions for oxytetracycline production were an initial pH of 5.2 to 6.3, an initial moisture content of 64% to 67%, supplementation with 20% (w/w) rice bran or 1.5% to 2.5% (w/w) (NH4)2SO4 as sole N source, 1.0% (w/w) CaCO3, 2% (w/w) MgSO4.7H2O, and 0.5% (w/w) KH2PO4, with incubation for 8 days at 25 to 30°C. Each g substrate produced 7 to 8 mg oxytetracycline.
在固态发酵中，玉米芯被用作里氏木霉 TM-55 生产土霉素的基质。第 4 天检测到土霉素，第 8 天达到最大值。土霉素生产的最佳条件为初始 pH 值为 5.2 至 6.3，初始水分含量为 64%至 67%，补充 20%（w/w）米糠或 1.5%至 2.5%（w/w）（NH4）2SO4 作为唯一氮源，1.0%（w/w）CaCO3，2%（w/w）MgSO4.7H2O 和 0.5%（w/w）KH2PO4，在 25 至 30°C 下培养 8 天。每克基质产生 7 至 8 毫克土霉素。
