Moon Yong-Suk, Sohn Dong-Seok, Moon Jee-Won, Lee Ju-Hyoung, Park In-Sook, Lee Jung-Kwang
*Professor, Department of Anatomy, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea. †Professor, Department of Dentistry and Oral and Maxillofacial Surgery, Catholic University Hospital of Daegu, Daegu, Republic of Korea. ‡Assistant Professor, Department of Dentistry and Oral and Maxillofacial Surgery, Catholic University Hospital of Daegu, Daegu, Republic of Korea. §Clinical Instructor, Department of Dentistry and Oral and Maxillofacial Surgery, Catholic University Hospital of Daegu, Daegu, Republic of Korea.
Implant Dent. 2014 Feb;23(1):29-36. doi: 10.1097/ID.0000000000000031.
The aim of this animal study was to evaluate, through histomorphometric evaluation, bone regeneration in rabbit maxillary sinuses with absorbable collagen membranes and osteoinductive replaceable bony windows over bone grafts.
Bilateral sinus augmentation procedures were performed in 16 adult male rabbits. The rabbits were randomly assigned to 4 groups of 4 rabbits each. Rectangular replaceable bony windows were made with a piezoelectric thin saw insert. In control group, grafted β-tricalcium phosphate (β-TCP) was covered by absorbable collagen membranes. In experimental groups, β-TCP was grafted and covered by replaceable bony windows. The rabbits were killed at 1, 2, 4, and 8 weeks postoperatively. The augmented sinuses were stained with hematoxylin-eosin and Masson trichrome stains and examined, under light microscopy, for newly formed bone and soft tissue changes in the maxillary sinuses.
Histologically, significantly higher and faster new bone formation was observed in the augmented sinuses of the experimental groups, receiving homologous replaceable bony windows than in those of the control group receiving collagen membranes.
This study demonstrates that, for augmentation, the use of the homologous replaceable bony window over bone graft material on the maxillary sinus accelerates bone regeneration.
本动物研究旨在通过组织形态计量学评估，研究在兔上颌窦中使用可吸收胶原膜和骨诱导性可置换骨窗覆盖骨移植材料时的骨再生情况。
对16只成年雄性兔进行双侧鼻窦增高术。将兔子随机分为4组，每组4只。使用压电薄片锯制作矩形可置换骨窗。对照组中，移植的β-磷酸三钙（β-TCP）用可吸收胶原膜覆盖。在实验组中，β-TCP移植后用可置换骨窗覆盖。术后1、2、4和8周处死兔子。对上颌窦增高部位进行苏木精-伊红染色和Masson三色染色，在光学显微镜下观察上颌窦中新形成的骨组织和软组织变化。
组织学观察显示，与接受胶原膜的对照组相比，接受同种异体可置换骨窗的实验组上颌窦增高部位新骨形成明显更高、更快。
本研究表明，在上颌窦骨移植材料上使用同种异体可置换骨窗进行增高术可加速骨再生。
