Omoruyi F O, Budiaman A, Eng Y, Olumese F E, Hoesel J L, Ejilemele A, Okorodudu A O
Department of Life Sciences, Texas A&M University-Corpus Christi, Center for the Sciences, 130B, 6300 Ocean Drive, Unit 5802, Corpus Christi, TX 78412, USA.
Department of Medical Biochemistry, University of Benin, Benin City, Nigeria.
Adv Pharmacol Sci. 2013;2013:172494. doi: 10.1155/2013/172494. Epub 2013 Dec 22.
In this study, the effect of phytic acid supplement on streptozotocin-induced diabetic rats was investigated. Diabetic rats were fed rodent chow with or without phytic acid supplementation for thirty days. Blood and organ samples were collected for assays. The average food intake was the highest and the body weight gain was the lowest in the group fed phytic acid supplement compared to the diabetic and normal control groups. There was a downward trend in intestinal amylase activity in the group fed phytic acid supplement compared to the other groups. The spike in random blood glucose was the lowest in the same group. We noted reduced serum triglycerides and increased total cholesterol and HDL cholesterol levels in the group fed phytic acid supplement. Serum alkaline phosphatase and alanine amino transferase activities were significantly (P < 0.05) increased by phytic acid supplementation. Systemic IL-1 β level was significantly (P < 0.05) elevated in the diabetic control and supplement treated groups. The liver lipogenic enzyme activities were not significantly altered among the groups. These results suggest that phytic acid supplementation may be beneficial in the management of diabetes mellitus. The observed adverse effect on the liver may be due to the combined effect of streptozotocin-induced diabetes and phytic acid supplementation.
在本研究中，研究了植酸补充剂对链脲佐菌素诱导的糖尿病大鼠的影响。给糖尿病大鼠喂食含或不含植酸补充剂的啮齿动物饲料，持续30天。采集血液和器官样本进行检测。与糖尿病对照组和正常对照组相比，喂食植酸补充剂的组平均食物摄入量最高，体重增加最低。与其他组相比，喂食植酸补充剂的组肠道淀粉酶活性呈下降趋势。同一组中随机血糖的峰值最低。我们注意到，喂食植酸补充剂的组血清甘油三酯降低，总胆固醇和高密度脂蛋白胆固醇水平升高。补充植酸后，血清碱性磷酸酶和丙氨酸转氨酶活性显著（P<0.05）升高。糖尿病对照组和补充剂治疗组的全身白细胞介素-1β水平显著（P<0.05）升高。各组间肝脏脂肪生成酶活性无显著变化。这些结果表明，补充植酸可能有助于糖尿病的管理。观察到的对肝脏的不良影响可能是链脲佐菌素诱导的糖尿病和补充植酸的联合作用所致。
