Addict Behav. 2014 Jan;39(1):345-9. doi: 10.1016/j.addbeh.2013.09.032.
Deficits in several aspects of executive cognitive functioning (ECF) have been consistently associated with alcohol use disorders. Most of this research, however, has been conducted in alcohol dependent patient samples. A handful of recent studies, primarily in college students, have also reported similar deficits, but little is known about the effects of heavy drinking in adult, non-patient men and women.
A community sample (N = 560) of men and women completed a brief battery of ECF measures including measures of attentional control, cognitive flexibility, working memory and response inhibition.Quantity/frequency of alcohol and illicit drug use in the past year were also assessed.
Regression analyses indicated that men and women with higher levels of alcohol consumption exhibited greater impairment on several ECF measures, primarily those pertaining to cognitive flexibility and response inhibition. These results remained after controlling for demographic factors such as age, gender, education, and illicit drug use.
These findings support and extend prior work documenting the deleterious effects of heavy alcohol consumption on ECF in a community sample and specifically indicate robust effects on cognitive flexibility,psychomotor speed, and response inhibition.
执行认知功能（ECF）的几个方面的缺陷一直与酒精使用障碍有关。然而，大多数此类研究都是在酒精依赖患者样本中进行的。最近的一些研究主要在大学生中进行，也报告了类似的缺陷，但对于成年非患者男性和女性的大量饮酒的影响知之甚少。
一项包括男性和女性在内的社区样本（N=560）完成了一系列简短的 ECF 测试，包括注意力控制、认知灵活性、工作记忆和反应抑制测试。还评估了过去一年中酒精和非法药物的使用量/频率。
回归分析表明，饮酒量较高的男性和女性在几项 ECF 测试中表现出更大的损伤，主要是与认知灵活性和反应抑制相关的测试。这些结果在控制了年龄、性别、教育程度和非法药物使用等人口统计学因素后仍然存在。
这些发现支持并扩展了先前的工作，即在社区样本中记录了大量饮酒对 ECF 的有害影响，特别是对认知灵活性、运动速度和反应抑制有明显影响。
