Söder Birgitta, Meurman Jukka H, Söder Per-Östen
Department of Dental Medicine, Karolinska Institutet, P.O. Box 4064, 14104 Huddinge, Sweden.
Institute of Dentistry and Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Central Hospital, PB 41, 00014 Helsinki, Finland.
Biomed Res Int. 2014;2014:569675. doi: 10.1155/2014/569675. Epub 2014 Jan 9.
We studied whether the amount of dental calculus is associated with death from heart infarction in the dental infection-atherosclerosis paradigm.
Participants were 1676 healthy young Swedes followed up from 1985 to 2011. At the beginning of the study all subjects underwent oral clinical examination including dental calculus registration scored with calculus index (CI). Outcome measure was cause of death classified according to WHO International Classification of Diseases. Unpaired t-test, Chi-square tests, and multiple logistic regressions were used.
Of the 1676 participants, 2.8% had died during follow-up. Women died at a mean age of 61.5 years and men at 61.7 years. The difference in the CI index score between the survivors versus deceased patients was significant by the year 2009 (P < 0.01). In multiple regression analysis of the relationship between death from heart infarction as a dependent variable and CI as independent variable with controlling for age, gender, dental visits, dental plaque, periodontal pockets, education, income, socioeconomic status, and pack-years of smoking, CI score appeared to be associated with 2.3 times the odds ratio for cardiac death.
The results confirmed our study hypothesis by showing that dental calculus indeed associated statistically with cardiac death due to infarction.
在牙齿感染-动脉粥样硬化范式中，我们研究了牙结石量是否与心肌梗死死亡相关。
参与者为1676名健康的瑞典年轻人，随访时间为1985年至2011年。研究开始时，所有受试者均接受口腔临床检查，包括用牙结石指数（CI）对牙结石进行登记评分。结局指标是根据世界卫生组织国际疾病分类确定的死亡原因。采用非配对t检验、卡方检验和多元逻辑回归分析。
在1676名参与者中，2.8%在随访期间死亡。女性死亡的平均年龄为61.5岁，男性为61.7岁。到2009年，存活者与死亡患者之间的CI指数评分差异具有统计学意义（P<0.01）。在以心肌梗死死亡为因变量、CI为自变量，并对年龄、性别、看牙次数、牙菌斑、牙周袋、教育程度、收入、社会经济地位和吸烟包年数进行控制的多元回归分析中，CI评分似乎与心脏死亡的比值比为2.3倍相关。
结果证实了我们的研究假设，表明牙结石确实与梗死导致的心脏死亡存在统计学关联。
