小鼠中补体受体相关基因的遗传组织
Genetic organization of complement receptor-related genes in the mouse.
作者信息
Kingsmore S F, Vik D P, Kurtz C B, Leroy P, Tack B F, Weis J H, Seldin M F
机构信息
Department of Medicine, Duke University, Durham, North Carolina 27710.
出版信息
J Exp Med. 1989 Apr 1;169(4):1479-84. doi: 10.1084/jem.169.4.1479.
Abstract
Using an interspecific cross, gene linkage relationships among members of the murine complement receptor-related genes, C4bp, Cfh, Mcry, and Mcr2, were analyzed by segregation of RFLP in 200 mice. The human homologues of these genes are tightly linked, composing the RCA locus, which maps to human chromosome (Chr.)1q32, within a large linkage group conserved between human Chr.1q21-32 and mouse Chr.1. RFLP associated with C4bp and Cfh map within this conserved linkage group; Cfh is located 9 cM telomeric to C4bp, which is consistent with linkage data for their human homologues. Mcry and Mcr2, while tightly linked, are located outside the conserved group, 40 cM telomeric to C4bp. These data suggest that a translocation or inversion occurred within the RCA family during the evolution of the mouse, defining a breakpoint of this large conserved linkage group.
摘要
利用种间杂交，通过对200只小鼠的限制性片段长度多态性（RFLP）进行分离分析，研究了小鼠补体受体相关基因C4bp、Cfh、Mcry和Mcr2成员之间的基因连锁关系。这些基因的人类同源基因紧密连锁，构成了RCA基因座，该基因座定位于人类染色体（Chr.）1q32，位于人类Chr.1q21 - 32和小鼠Chr.1之间保守的大的连锁群内。与C4bp和Cfh相关的RFLP定位于这个保守的连锁群内；Cfh位于C4bp端粒方向9厘摩处，这与其人类同源基因的连锁数据一致。Mcry和Mcr2虽然紧密连锁，但位于保守群之外，在C4bp端粒方向40厘摩处。这些数据表明，在小鼠进化过程中，RCA家族内发生了易位或倒位，确定了这个大的保守连锁群的一个断点。
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