糖基阵列作为传染病研究的工具。

Glycan arrays as tools for infectious disease research.

机构信息

Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14424 Potsdam, Germany; Institute for Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany.

Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14424 Potsdam, Germany.

出版信息

Curr Opin Chem Biol. 2014 Feb;18:38-45. doi: 10.1016/j.cbpa.2013.11.013. Epub 2013 Dec 30.

DOI:10.1016/j.cbpa.2013.11.013

PMID:24534751

Abstract

Infectious diseases cause millions of deaths worldwide each year and are a major burden for economies, especially in underdeveloped countries. Glycans and their interactions with other biomolecules are involved in all major steps of infection. Glycan arrays enable the rapid and sensitive detection of those interactions and are among the most powerful techniques to study the molecular biology of infectious diseases. This review will focus on recent developments and discuss the applications of glycan arrays to the elucidation of host-pathogen and pathogen-pathogen interactions, the development of tools for infection diagnosis and the use of glycan arrays in modern vaccine design.

摘要

传染病每年在全球造成数百万人死亡，是经济的主要负担，尤其是在欠发达国家。聚糖及其与其他生物分子的相互作用参与了感染的所有主要步骤。糖基阵列能够快速灵敏地检测这些相互作用，是研究传染病分子生物学最有力的技术之一。本文将重点介绍最新的发展，并讨论糖基阵列在阐明宿主-病原体和病原体-病原体相互作用、开发感染诊断工具以及在现代疫苗设计中的应用。