Food Security Research Center, and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
J Nutr. 2012 Feb;142(2):334-9. doi: 10.3945/jn.111.146167. Epub 2011 Dec 21.
Independent association between legume intake and systemic inflammation is not well documented. The traditional Iranian diet provides an opportunity to assess the association between legume intake and health outcomes. This study was carried out to examine legume consumption in relation to serum concentrations of adhesion molecules and inflammatory biomarkers among Iranian women. In this cross-sectional study, 486 Tehrani female teachers were investigated. A trained dietitian administered a validated semiquantitative FFQ for assessment of usual dietary intakes. Legume intake was calculated by summing up the consumption of lentils, peas, chickpeas, different kinds of beans including broad beans, and chickling vetch. To measure serum concentrations of adhesion molecules and inflammatory biomarkers, a fasting blood sample was taken. After statistically controlling for potential confounders, individuals in the highest tertile of legume intake had lower serum concentrations of E-selectin (percent difference between the lowest and highest tertile: -14.1%; P = 0.04), soluble intercellular adhesion molecule-1 (-20.3%; P < 0.01), and soluble vascular cell adhesion molecule-1 (-15.6%; P = 0.01) compared with those in the lowest tertile. Legume intake was inversely associated with serum concentrations of high sensitive CRP (hs-CRP), TNFα, and IL-6, even after controlling for potential confounders and dietary variables (percent difference between the lowest and highest tertile for hs-CRP: -39.2%, P < 0.001; for TNFα: -15.9%, P = 0.04; and for IL-6: -39.5%, P < 0.01). Legume intake and concentrations of serum amyloid A were not correlated. Legume consumption is inversely associated with serum concentrations of adhesion molecules and inflammatory biomarkers among Iranian women.
豆类摄入量与全身炎症之间的独立关联尚未得到充分证实。传统的伊朗饮食为评估豆类摄入量与健康结果之间的关系提供了机会。本研究旨在研究豆类消费与伊朗女性血清黏附分子和炎症生物标志物浓度之间的关系。在这项横断面研究中，调查了 486 名德黑兰女教师。一名经过培训的营养师使用经过验证的半定量 FFQ 来评估习惯性饮食摄入量。豆类摄入量通过汇总小扁豆、豌豆、鹰嘴豆、各种豆类（包括蚕豆和小巢菜）和兵豆的消耗量来计算。为了测量血清黏附分子和炎症生物标志物的浓度，采集了空腹血样。在对潜在混杂因素进行统计学控制后，豆类摄入量最高 tertile 的个体血清 E-选择素浓度较低（最低 tertile 与最高 tertile 之间的百分比差异：-14.1%；P = 0.04），可溶性细胞间黏附分子-1（-20.3%；P < 0.01）和可溶性血管细胞黏附分子-1（-15.6%；P = 0.01）与最低 tertile 相比。即使在控制潜在混杂因素和饮食变量后，豆类摄入量与血清高敏 C 反应蛋白（hs-CRP）、TNFα 和 IL-6 浓度呈负相关（hs-CRP 最低 tertile 与最高 tertile 之间的百分比差异：-39.2%，P < 0.001；TNFα：-15.9%，P = 0.04；IL-6：-39.5%，P < 0.01）。豆类摄入量与血清淀粉样蛋白 A 浓度无相关性。豆类消费与伊朗女性血清黏附分子和炎症生物标志物浓度呈负相关。
