Rodriguez Elisenda, Lelyveld Victor S, Atanasijevic Tatjana, Okada Satoshi, Jasanoff Alan
Departments of Biological Engineering, Brain & Cognitive Sciences, and Nuclear Science & Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Chem Commun (Camb). 2014 Apr 7;50(27):3595-8. doi: 10.1039/c4cc00314d. Epub 2014 Feb 24.
Magnetic nanoparticle-based sensors for MRI have been accelerated to a timescale of seconds using densely-functionalized particles of small size. Parameters that increase response rates also result in large nuclear magnetic relaxation rate and light scattering changes, allowing signals to be detected almost immediately after changes in calcium concentration.
基于磁性纳米颗粒的磁共振成像（MRI）传感器已通过使用小尺寸的密集功能化颗粒加速到秒级时间尺度。提高响应速率的参数也会导致大的核磁弛豫率和光散射变化，从而使在钙浓度变化后几乎能立即检测到信号。
