Gurgul Artur, Semik Ewelina, Pawlina Klaudia, Szmatoła Tomasz, Jasielczuk Igor, Bugno-Poniewierska Monika
Laboratory of Genomics, National Research Institute of Animal Production, Krakowska 1, 32-083, Balice, Poland,
J Appl Genet. 2014 May;55(2):197-208. doi: 10.1007/s13353-014-0202-4. Epub 2014 Feb 25.
Animal genomics is currently undergoing dynamic development, which is driven by the flourishing of high-throughput genome analysis methods. Recently, a large number of animals has been genotyped with the use of whole-genome genotyping assays in the course of genomic selection programmes. The results of such genotyping can also be used for studies on different aspects of livestock genome functioning and diversity. In this article, we review the recent literature concentrating on various aspects of animal genomics, including studies on linkage disequilibrium, runs of homozygosity, selection signatures, copy number variation and genetic differentiation of animal populations. Our work is aimed at providing insight into certain achievements of animal genomics and to arouse interest in basic research on the complexity and structure of the genomes of livestock.
动物基因组学目前正在经历动态发展,这是由高通量基因组分析方法的蓬勃发展所驱动的。最近,在基因组选择计划过程中,大量动物已通过全基因组基因分型检测进行了基因分型。这种基因分型的结果也可用于家畜基因组功能和多样性不同方面的研究。在本文中,我们回顾了近期文献,重点关注动物基因组学的各个方面,包括连锁不平衡、纯合子片段、选择印记、拷贝数变异以及动物群体的遗传分化研究。我们的工作旨在深入了解动物基因组学的某些成就,并激发对家畜基因组复杂性和结构基础研究的兴趣。