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解除武装的密度：免疫刺激树突状细胞的糖酵解突破？

Disarmed by density: A glycolytic break for immunostimulatory dendritic cells?

机构信息

Department of Microbiology; Tumor and Cell Biology; Karolinska Institutet; Stockholm, Sweden.

出版信息

Oncoimmunology. 2013 Dec 1;2(12):e26744. doi: 10.4161/onci.26744. Epub 2013 Oct 22.

DOI:10.4161/onci.26744
PMID:24575378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3926870/
Abstract

We observed a cell concentration-dependent differentiation switch among cultured dendritic cells (DCs) triggered by lactic acid, a product of glycolytic metabolism. In particular, while interleukin (IL)-12, IL-23, and tumor necrosis factor α (TNFα)-producing, migratory DCs developed in sparse cultures, IL-10-producing, non-migratory DCs differentiated in dense cultures. This points to a novel opportunity for tailoring DC-based anticancer therapies through metabolism modulation in developing DCs.

摘要

我们观察到，培养的树突状细胞 (DC) 在乳酸的作用下发生细胞浓度依赖性分化转换，乳酸是糖酵解代谢的产物。具体而言，稀疏培养时会产生产生白细胞介素 (IL)-12、IL-23 和肿瘤坏死因子 α (TNFα) 的迁移型 DC，而在密集培养时则分化为产生 IL-10 的非迁移型 DC。这为通过调节正在发育的 DC 中的代谢来定制基于 DC 的抗癌疗法提供了新的机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa3d/3926870/01ea269730b8/onci-2-e26744-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa3d/3926870/01ea269730b8/onci-2-e26744-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa3d/3926870/01ea269730b8/onci-2-e26744-g1.jpg

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