Bioengineering Laboratory, Department of Textile Technology, Indian Institute of Technology Delhi, New Delhi, 110016, India,
J Mater Sci Mater Med. 2014 Jun;25(6):1613-22. doi: 10.1007/s10856-014-5184-6. Epub 2014 Mar 6.
The aim of the present study was to develop PVA/PEO/CMC/aloe vera (PPCAV) and PVA/PEO/CMC/curcumin (PPCCu) dressings with nonwoven polyester fabric as the support layer via freeze-drying (FD) approach. Tetracycline hydrochloride drug (TC) was loaded along with curcumin and aloe vera on these dressings. The morphology of the dressings was characterized by scanning electron microscopy. The swelling behavior, water vapor transmission rate (WVTR), in vitro drug release and antimicrobial nature were analyzed to assess the applicability of these freeze-dried membranes as wound dressing materials. The results show that these dressings made from PPCAVTC and PPCCuTC were highly porous with three-dimensional interconnected porous morphology. The cumulative release of drug from the dressings increases with increasing immersion time and continued up to 24 h, after that it gets leveled off. These dressings evidenced wonderful antimicrobial nature in vitro. These dressings were found to have more than 900 % PBS uptake, WVTR was found to be in the range 2,000-2,500 gm(-2) day(-1). These dressings possess many characteristics desirable in an ideal wound dressing material.
本研究旨在通过冷冻干燥（FD）法制备以非织造聚酯纤维为支撑层的 PVA/PEO/CMC/芦荟（PPCAV）和 PVA/PEO/CMC/姜黄素（PPCCu）敷料，并在这些敷料上载四环素盐酸药物（TC）和姜黄素、芦荟。通过扫描电子显微镜对敷料的形态进行了表征。分析了这些冻干膜的溶胀行为、水蒸气透过率（WVTR）、体外药物释放和抗菌性能，以评估它们作为伤口敷料材料的适用性。结果表明，PPCAVTC 和 PPCCuTC 制成的这些敷料具有高度多孔性，具有三维互联多孔形态。药物从敷料中的累积释放随着浸渍时间的增加而增加，持续 24 小时后趋于稳定。这些敷料在体外表现出良好的抗菌性能。这些敷料在 PBS 中的吸水率超过 900%，WVTR 在 2000-2500 gm(-2) day(-1)范围内。这些敷料具有理想伤口敷料材料所需的许多特性。
