多能干细胞可用于基于细胞的治疗吗？
Can pluripotent stem cells be used in cell-based therapy?
作者信息
Picanço-Castro Virginia, Moreira Lilian F, Kashima Simone, Covas Dimas T
机构信息
Blood Center of Ribeirão Preto , Ribeirão Preto, Brazil, 14022-000.
出版信息
Cell Reprogram. 2014 Apr;16(2):98-107. doi: 10.1089/cell.2013.0072. Epub 2014 Mar 7.
Abstract
Pluripotent stem cells, both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), have the ability to differentiate into several cell types that can be used in drug testing and also in the study and treatment of diseases. These cells can be differentiated by in vitro systems, which may serve as models for human diseases and for cell transplantation. In this review, we address the pluripotent cell types, how to obtain and characterize these cells, and differentiation assays. We also focus on the potential of these cells in clinical trials, and we describe the clinical trials that are underway.
摘要
多能干细胞，包括胚胎干细胞（ESC）和诱导多能干细胞（iPSC），具有分化为多种细胞类型的能力，可用于药物测试以及疾病的研究和治疗。这些细胞可通过体外系统进行分化，该系统可作为人类疾病和细胞移植的模型。在本综述中，我们探讨了多能细胞类型、如何获取和表征这些细胞以及分化测定。我们还关注这些细胞在临床试验中的潜力，并描述正在进行的临床试验。
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