Department of Medicine, The George Washington University, 2150 Pennsylvania Avenue, Washington, DC, 20037, USA,
Theor Med Bioeth. 2014 Apr;35(2):143-56. doi: 10.1007/s11017-014-9288-2.
The risks of harm to nonhuman primates, and the absence of benefits for them, are critically important to decisions about nonhuman primate research. Current guidelines for review and practice tend to be permissive for nonhuman primate research as long as minimal welfare requirements are fulfilled and human medical advances are anticipated. This situation is substantially different from human research, in which risks of harms to the individual subject are typically reduced to the extent feasible. A risk threshold is needed for the justification of research on nonhuman primates, comparable to the way risk thresholds are set for vulnerable human subjects who cannot provide informed consent. Much of the laboratory research conducted today has inadequate standards, leading to common physical, psychological, and social harms.
非人类灵长类动物所面临的伤害风险，以及它们从中无法获益，对非人类灵长类动物研究决策至关重要。目前的审查和实践指南往往对非人类灵长类动物研究持宽容态度，只要满足最低福利要求并预期能推动人类医学进步即可。这种情况与人类研究有很大不同，在人类研究中，通常会尽可能地降低对个体研究对象造成伤害的风险。需要为非人类灵长类动物研究设定一个风险阈值，类似于为无法提供知情同意的弱势人类研究对象设定风险阈值的方式。如今进行的许多实验室研究都没有达到足够的标准，导致了常见的身体、心理和社会伤害。
