Penders John, Gerhold Kerstin, Thijs Carel, Zimmermann Kurt, Wahn Ulrich, Lau Susanne, Hamelmann Eckard
Department of Medical Microbiology; School for Nutrition, Toxicology, and Metabolism; Maastricht University Medical Centre; Maastricht, the Netherlands; Department of Epidemiology; School for Public Health and Primary Care; Maastricht University; Maastricht, the Netherlands.
Department of Pediatric Pneumology and Immunology; Charité-Universitätsmedizin Berlin; Berlin, Germany.
Gut Microbes. 2014 Mar-Apr;5(2):239-44. doi: 10.4161/gmic.27905. Epub 2014 Jan 23.
There is convincing evidence from both human and animal studies suggesting that the infant intestinal microbiota plays an important role in regulating immune responses associated with the development of allergic diseases. To date there are, however, still no definite bacterial taxa or particular subsets of the microbiota that have been consistently associated with allergic diseases, which is mainly attributable to the methodological dissimilarities between studies. As such there is a need to apply different methodological concepts to enhance a deeper and more refined understanding of the relationship between the gut microbiota and allergies. Within our recent studies we reported that colonization by clostridia in early infancy increased the risk of atopic dermatitis. Using subsequent mediation analysis, we demonstrated that birth mode and having older siblings strongly impacted the infant microbiota which in turn affected the risk of atopic dermatitis. The results of these mediation analyses contributed stronger evidence for a causal link of birth mode and birth order on allergy risk through modulation of the microbiota composition.
来自人体和动物研究的有力证据表明，婴儿肠道微生物群在调节与过敏性疾病发展相关的免疫反应中发挥着重要作用。然而，迄今为止，仍没有明确的细菌分类群或微生物群的特定亚群与过敏性疾病始终相关，这主要归因于研究之间的方法差异。因此，需要应用不同的方法概念，以更深入、更精细地理解肠道微生物群与过敏之间的关系。在我们最近的研究中，我们报告称，婴儿早期梭菌定植会增加患特应性皮炎的风险。通过后续的中介分析，我们证明出生方式和有哥哥姐姐会强烈影响婴儿微生物群，进而影响患特应性皮炎的风险。这些中介分析的结果为出生方式和出生顺序通过调节微生物群组成对过敏风险的因果联系提供了更强有力的证据。
