VCU Philips Institute; Virginia Commonwealth University; Richmond, VA USA; Center for the Study of Biological Complexity; Virginia Commonwealth University; Richmond, VA USA; Department of Microbiology and Immunology; Virginia Commonwealth University; Richmond, VA USA.
Periodontics Department; Virginia Commonwealth University; Richmond, VA USA.
Virulence. 2014 Apr 1;5(3):424-32. doi: 10.4161/viru.28532. Epub 2014 Mar 18.
Oral diseases including periodontal disease and caries are some of the most prevalent infectious diseases in humans. Different microbial species cohabitate and form a polymicrobial biofilm called dental plaque in the oral cavity. Metagenomics using next generation sequencing technologies has produced bacterial profiles and genomic profiles to study the relationships between microbial diversity, genetic variation, and oral diseases. Several oral metagenomic studies have examined the oral microbiome of periodontal disease and caries. Gene annotations in these studies support the association of specific genes or metabolic pathways with oral health and with specific diseases. The roles of pathogenic species and functions of specific genes in oral disease development have been recognized by metagenomic analysis. A model is proposed in which three levels of interactions occur in the oral microbiome that determines oral health or disease.
口腔疾病包括牙周病和龋齿，是人类最常见的传染病之一。不同的微生物物种在口腔中共存，并形成一种被称为牙菌斑的多微生物生物膜。使用下一代测序技术的宏基因组学已经产生了细菌和基因组图谱，以研究微生物多样性、遗传变异与口腔疾病之间的关系。几项口腔宏基因组研究检查了牙周病和龋齿的口腔微生物组。这些研究中的基因注释支持特定基因或代谢途径与口腔健康和特定疾病的关联。通过宏基因组分析，已经认识到病原物种的作用和特定基因在口腔疾病发展中的功能。提出了一个模型，其中口腔微生物组中存在三个相互作用的层次，决定了口腔的健康或疾病状态。
