Jensen Michael K, Skriver Karen
Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, Copenhagen, Denmark.
IUBMB Life. 2014 Mar;66(3):156-166. doi: 10.1002/iub.1256. Epub 2014 Mar 23.
Plant-specific NAM/ATAF/CUC (NAC) transcription factors (TFs) have recently received considerable attention due to their significant roles in plant development and stress signaling. Here, we summarize progress in understanding NAC TFs in stress responses and senescence. We focus on interactions between the DNA-binding NAC domain and target genes, and between the large, mostly disordered transcription regulatory domain of NAC TFs and protein interaction partners. Recent studies have identified both up-stream regulators of NAC genes and down-stream NAC target genes, outlining regulatory networks associated with NAC-protein interactions. This connects molecular interactions and signal pathway intersections with biological functions with promising use in agriculture. © 2014 IUBMB Life, 66(3):156-166, 2014.
植物特有的NAM/ATAF/CUC（NAC）转录因子（TFs）因其在植物发育和胁迫信号传导中的重要作用，近来受到了广泛关注。在此，我们总结了在理解NAC转录因子在胁迫响应和衰老方面的研究进展。我们重点关注DNA结合NAC结构域与靶基因之间的相互作用，以及NAC转录因子大多无序的大型转录调节结构域与蛋白质相互作用伙伴之间的相互作用。最近的研究已经鉴定出NAC基因的上游调节因子和下游NAC靶基因，勾勒出了与NAC-蛋白质相互作用相关的调控网络。这将分子相互作用和信号通路交叉与生物学功能联系起来，有望在农业中得到应用。©国际生物化学与分子生物学联盟生命科学，66(3):156 - 166，2014年。
