Larson Eric, Lee Adrian K C
Institute for Learning and Brain Sciences, University of Washington , Seattle, WA , USA.
Institute for Learning and Brain Sciences, University of Washington , Seattle, WA , USA ; Department of Speech and Hearing Sciences, University of Washington , Seattle, WA , USA.
Front Hum Neurosci. 2014 Mar 13;8:151. doi: 10.3389/fnhum.2014.00151. eCollection 2014.
Magnetoencephalography (MEG) provides a direct, non-invasive view of neural activity with millisecond temporal precision. Recent developments in MEG analysis allow for improved source localization and mapping of connectivity between brain regions, expanding the possibilities for using MEG as a diagnostic tool. In this paper, we first describe inverse imaging methods (e.g., minimum-norm estimation) and functional connectivity measures, and how they can provide insights into cortical processing. We then offer a perspective on how these techniques could be used to understand and evaluate auditory pathologies that often manifest during development. Here we focus specifically on how MEG inverse imaging, by providing anatomically based interpretation of neural activity, may allow us to test which aspects of cortical processing play a role in (central) auditory processing disorder [(C)APD]. Appropriately combining auditory paradigms with MEG analysis could eventually prove useful for a hypothesis-driven understanding and diagnosis of (C)APD or other disorders, as well as the evaluation of the effectiveness of intervention strategies.
脑磁图（MEG）能够以毫秒级的时间精度直接、无创地观察神经活动。MEG分析的最新进展使得脑区之间的源定位和连接图谱得到改进，拓展了将MEG用作诊断工具的可能性。在本文中，我们首先描述逆成像方法（如最小范数估计）和功能连接测量方法，以及它们如何能够深入了解皮层处理过程。然后，我们就如何利用这些技术来理解和评估发育过程中经常出现的听觉病理状况提出一种观点。在此，我们特别关注MEG逆成像如何通过提供基于解剖学的神经活动解释，使我们能够检验皮层处理的哪些方面在中枢听觉处理障碍（(C)APD）中发挥作用。将听觉范式与MEG分析适当地结合起来，最终可能有助于以假设驱动的方式理解和诊断(C)APD或其他疾病，以及评估干预策略的有效性。
