van Nierop Gijsbert P, Hintzen Rogier Q, Verjans Georges M G M
Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
J Neurovirol. 2014 Aug;20(4):412-8. doi: 10.1007/s13365-014-0248-4. Epub 2014 Mar 27.
Prevalence of eight human herpesviruses (HHV1-8) was determined by real-time PCR in cell-rich cerebrospinal fluid (CSF) samples, obtained early after disease symptoms, of Dutch patients with multiple sclerosis (MS) and other noninfectious central nervous system diseases (NIND). Whereas HHV1-8 DNA was undetectable in CSF samples of MS patients, HHV6 DNA was detected in a plexus neuritis case and HHV7 DNA in an ependymoma and a Behçets' disease patient. However, intrathecal HHV infection was not detected. Data indicate that HHV1-8 are rarely detected in CSF of Dutch NIND patients and do not support the role of intrathecal HHV infection early after onset of disease symptoms in MS.
通过实时聚合酶链反应（PCR），对荷兰多发性硬化症（MS）患者和其他非感染性中枢神经系统疾病（NIND）患者在出现疾病症状后早期获取的富含细胞的脑脊液（CSF）样本中8种人类疱疹病毒（HHV1 - 8）的流行情况进行了测定。在MS患者的CSF样本中未检测到HHV1 - 8 DNA，但在1例多发性神经炎病例中检测到HHV6 DNA，在1例室管膜瘤患者和1例白塞病患者中检测到HHV7 DNA。然而，未检测到鞘内HHV感染。数据表明，在荷兰NIND患者的CSF中很少检测到HHV1 - 8，且不支持在MS疾病症状出现后早期鞘内HHV感染所起的作用。
