Magge Suma, Lembo Anthony
Dr. Magge is a Fellow and Dr. Lembo is an Associate Professor of Medicine in the Division of Gastroenterology at Beth Israel Deaconess Medical Center in Boston, Massachusetts.
Gastroenterol Hepatol (N Y). 2012 Nov;8(11):739-45.
Functional bowel disorders, including irritable bowel syndrome (IBS), are common disorders that have a significant impact on patients' quality of life. These disorders present major challenges to healthcare providers, as few effective medical therapies are currently available. Recently, there has been increasing interest in dietary therapies for IBS, particularly a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs). Since ingestion of FODMAPs increases the delivery of readily fermentable substrates and water to the distal small intestine and colon-which results in luminal distention and gas-the reduction of FODMAPs in a patient's diet may improve functional gastrointestinal symptoms. This paper will review the pathophysiology of IBS and the role of FODMAPs for the treatment of this condition.
功能性肠病，包括肠易激综合征（IBS），是常见疾病，对患者的生活质量有重大影响。这些疾病给医疗服务提供者带来了重大挑战，因为目前几乎没有有效的药物治疗方法。最近，人们对IBS的饮食疗法越来越感兴趣，特别是低发酵性寡糖、双糖、单糖和多元醇（FODMAPs）饮食。由于摄入FODMAPs会增加易发酵底物和水分向远端小肠和结肠的输送，这会导致肠腔扩张和气体产生，因此减少患者饮食中的FODMAPs可能会改善功能性胃肠道症状。本文将综述IBS的病理生理学以及FODMAPs在治疗这种疾病中的作用。
