Center for Evolutionary Nanoparticles (CEN), Department of Chemistry, Yonsei University , Seoul 120-749, Korea.
ACS Nano. 2014 Apr 22;8(4):3393-401. doi: 10.1021/nn405977t. Epub 2014 Mar 27.
One of the holy grails in biomedical imaging technology is to achieve accurate imaging of biological targets. The development of sophisticated instrumentation and the use of contrast agents have improved the accuracy of biomedical imaging. However, the issue of false imaging remains a problem. Here, we developed a dual-mode artifact filtering nanoparticle imaging agent (AFIA) that comprises a combination of paramagnetic and superparamagnetic nanomaterials. This AFIA has the ability to perform "AND logic gate" algorithm to eliminate false errors (artifacts) from the raw images to enhance accuracy of the MRI. We confirm the artifact filtering capability of AFIA in MRI phantoms and further demonstrate that artifact-free imaging of stem cell migration is possible in vivo.
在生物医学成像技术中，有一个圣杯目标，就是实现对生物靶标的精确成像。复杂仪器的发展和对比剂的使用提高了生物医学成像的准确性。然而，假成像的问题依然存在。在这里，我们开发了一种双模伪影过滤纳米颗粒成像剂（AFIA），它由顺磁和超顺磁纳米材料的组合构成。这种 AFIA 能够执行“与门”算法，从原始图像中消除假误差（伪影），从而提高 MRI 的准确性。我们在 MRI 体模中证实了 AFIA 的伪影过滤能力，并进一步证明了在体内实现无伪影的干细胞迁移成像成为可能。
