College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, Shandong Province 266003, China; Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA.
Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA.
J Food Drug Anal. 2014 Mar;22(1):86-94. doi: 10.1016/j.jfda.2014.01.007. Epub 2014 Feb 5.
Nano-iron metal and nano-iron oxides are among the most widely used engineered and naturally occurring nanostructures, and the increasing incidence of biological exposure to these nanostructures has raised concerns about their biotoxicity. Reactive oxygen species (ROS)-induced oxidative stress is one of the most accepted toxic mechanisms and, in the past decades, considerable efforts have been made to investigate the ROS-related activities of iron nanostructures. In this review, we summarize activities of nano-iron metal and nano-iron oxides in ROS-related redox processes, addressing in detail the known homogeneous and heterogeneous redox mechanisms involved in these processes, intrinsic ROS-related properties of iron nanostructures (chemical composition, particle size, and crystalline phase), and ROS-related bio-microenvironmental factors, including physiological pH and buffers, biogenic reducing agents, and other organic substances.
纳米铁金属和纳米氧化铁是应用最广泛的工程纳米结构和天然纳米结构之一，生物接触这些纳米结构的频率不断增加，引起了人们对其生物毒性的关注。活性氧（ROS）诱导的氧化应激是最被认可的毒性机制之一，在过去几十年中，人们做出了大量努力来研究铁纳米结构与 ROS 相关的活性。在这篇综述中，我们总结了纳米铁金属和纳米氧化铁在 ROS 相关的氧化还原过程中的活性，详细介绍了这些过程中涉及的已知均相和非均相氧化还原机制、铁纳米结构的固有 ROS 相关特性（化学组成、粒径和晶体相）以及 ROS 相关的生物微环境因素，包括生理 pH 值和缓冲液、生物还原剂和其他有机物质。
