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跑步机跑步对大鼠模型膝关节软骨的强度依赖性效应

Intensity-dependent effect of treadmill running on knee articular cartilage in a rat model.

作者信息

Ni Guo-Xin, Liu Sheng-Yao, Lei Lei, Li Zhe, Zhou Yue-Zhu, Zhan Li-Qiong

机构信息

Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue (N), Guangzhou 510515, China.

Department of Rehabilitation Medicine, Longyan People's Hospital, 31 Denggao Road (W), Longyan 364000, China.

出版信息

Biomed Res Int. 2013;2013:172392. doi: 10.1155/2013/172392. Epub 2013 Dec 31.

DOI:10.1155/2013/172392
PMID:24693534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3892754/
Abstract

OBJECTIVE

To understand the changes of femoral cartilage in response to treadmill running with different intensities in the hope of differentiating "moderate" and "strenuous" running in a rat model.

METHOD

A total of 24 male Wistar rats were randomly assigned into groups of sedentary (SED), low-intensity running (LIR), medium-intensity running (MIR), and high-intensity running (HIR). Rats in LIR, MIR, and HIR groups underwent 8 weeks' treadmill running programs. After sacrificed, femoral condyles were collected to take histomorphometric analysis and immunohistochemistry for collagen II.

RESULTS

Gross and histological observation showed osteoarthritic changes in group HIR. In comparison to SED group, there was significant increase in cartilage thickness, number of chondrocytes, and GAG content in groups LIR and MIR. Conversely, decrease in cartilage thickness, chondrocyte number, and GAG content was found in rats of HIR group, without significant difference though. In addition, in comparison to SED group, HIR group exhibited disorganization of collagen fibril and significantly lower content of collagen type II.

CONCLUSION

An intensity-dependent effect was suggested on the articular cartilage. Our results also demonstrated that running with low-to-medium intensity applied in the present study should be regarded as "moderate" running, whereas high-intensity running as "strenuous" running.

摘要

目的

了解不同强度跑步机跑步后股骨软骨的变化，以期在大鼠模型中区分“适度”和“剧烈”跑步。

方法

将24只雄性Wistar大鼠随机分为久坐组（SED）、低强度跑步组（LIR）、中等强度跑步组（MIR）和高强度跑步组（HIR）。LIR、MIR和HIR组的大鼠进行为期8周的跑步机跑步计划。处死大鼠后，收集股骨髁进行组织形态计量学分析和II型胶原免疫组织化学检测。

结果

大体和组织学观察显示HIR组有骨关节炎改变。与SED组相比，LIR组和MIR组的软骨厚度、软骨细胞数量和糖胺聚糖（GAG）含量显著增加。相反，HIR组大鼠的软骨厚度、软骨细胞数量和GAG含量降低，不过差异无统计学意义。此外，与SED组相比，HIR组胶原纤维排列紊乱，II型胶原含量显著降低。

结论

提示关节软骨存在强度依赖性效应。我们的结果还表明，本研究中应用的低至中等强度跑步应被视为“适度”跑步，而高强度跑步则为“剧烈”跑步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45fc/3892754/758a84e8b7bb/BMRI2013-172392.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45fc/3892754/c8b2908a83a0/BMRI2013-172392.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45fc/3892754/910615cad424/BMRI2013-172392.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45fc/3892754/daee401f52f9/BMRI2013-172392.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45fc/3892754/bf7abd595b00/BMRI2013-172392.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45fc/3892754/758a84e8b7bb/BMRI2013-172392.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45fc/3892754/c8b2908a83a0/BMRI2013-172392.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45fc/3892754/910615cad424/BMRI2013-172392.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45fc/3892754/daee401f52f9/BMRI2013-172392.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45fc/3892754/bf7abd595b00/BMRI2013-172392.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45fc/3892754/758a84e8b7bb/BMRI2013-172392.005.jpg

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