Fornieles G, Rosety M A, Elosegui S, Rosety J M, Alvero-Cruz J R, Garcia N, Rosety M, Rodriguez-Pareja T, Toro R, Rosety-Rodriguez M, Ordonez F J, Rosety I
School of Medicine, University of Cadiz, Cadiz, Spain.
School of Sports Sciences, University of Cadiz, Cadiz, Spain.
Braz J Med Biol Res. 2014 Apr;47(4):345-8. doi: 10.1590/1414-431x20143468. Epub 2014 Mar 28.
This study was designed to assess the influence of resistance training on salivary immunoglobulin A (IgA) levels and hormone profile in sedentary adults with Down syndrome (DS). A total of 40 male adults with DS were recruited for the trial through different community support groups for people with intellectual disabilities. All participants had medical approval for participation in physical activity. Twenty-four adults were randomly assigned to perform resistance training in a circuit with six stations, 3 days per week for 12 weeks. Training intensity was based on functioning in the eight-repetition maximum (8RM) test for each exercise. The control group included 16 age-, gender-, and BMI-matched adults with DS. Salivary IgA, testosterone, and cortisol levels were measured by ELISA. Work task performance was assessed using the repetitive weighted-box-stacking test. Resistance training significantly increased salivary IgA concentration (P=0.0120; d=0.94) and testosterone levels (P=0.0088; d=1.57) in the exercising group. Furthermore, it also improved work task performance. No changes were seen in the controls who had not exercised. In conclusion, a short-term resistance training protocol improved mucosal immunity response as well as salivary testosterone levels in sedentary adults with DS.
本研究旨在评估阻力训练对唐氏综合征（DS）久坐不动的成年患者唾液免疫球蛋白A（IgA）水平和激素谱的影响。通过不同的智障人士社区支持小组招募了总共40名患有DS的成年男性参与试验。所有参与者均获得参与体育活动的医学批准。24名成年人被随机分配到一个有六个站点的循环中进行阻力训练，每周3天，共12周。训练强度基于每项运动的八次重复最大值（8RM）测试中的功能表现。对照组包括16名年龄、性别和体重指数相匹配的患有DS的成年人。唾液IgA、睾酮和皮质醇水平通过酶联免疫吸附测定法（ELISA）测量。使用重复加权箱堆叠测试评估工作任务表现。阻力训练显著提高了运动组的唾液IgA浓度（P = 0.0120；d = 0.94）和睾酮水平（P = 0.0088；d = 1.57）。此外，它还改善了工作任务表现。未运动的对照组没有变化。总之，一个短期的阻力训练方案改善了DS久坐不动成年患者的黏膜免疫反应以及唾液睾酮水平。
