School of Medicine, University of Cadiz, Cadiz, Spain.
Federazione Italiana Pallacanestro in Carrozina (FIPIC), School of Sports Medicine, University La Sapienza, Rome, Italy.
Oxid Med Cell Longev. 2021 Jan 19;2021:8811153. doi: 10.1155/2021/8811153. eCollection 2021.
Previous studies have found aerobic training improved oxidative damage in people with Down syndrome (DS). However, there is a lack of information regarding the influence of resistance training on redox imbalance in this population. Accordingly, this study was conducted to determine the effect of resistance training (RT) on antioxidant defence system in sedentary adults with DS. Thirty-six male adults with DS were recruited through different community support groups. Eighteen were randomly assigned to perform a circuit RT program with 6 stations, 3 days/week for 12 weeks. Plasma total antioxidant status (TAS), reduced glutathione (GHS), ascorbate, serum -tocopherol, and erythrocyte glutathione reductase activity were assessed. Plasma malondialdehyde (MDA) and carbonyl groups (CG) were assessed as markers of oxidative damage. Muscle strength was also measured. Dynamic torque of knee extensors and flexors as well as maximal handgrip strength was significantly improved after the completion of the training program. Plasma levels of TAS and erythrocyte glutathione reductase (GR) activity were significantly increased. Conversely, MDA and CG levels were significantly reduced. It was concluded RT improved antioxidant defence system and reduced oxidative damage in adults with DS. Further, long-term studies are required to determine whether the increased antioxidant system may improve clinical outcomes of adults with DS.
先前的研究发现，有氧运动可改善唐氏综合征（DS）患者的氧化损伤。然而，关于抗阻训练对该人群氧化还原失衡的影响，相关信息还很缺乏。因此，本研究旨在确定抗阻训练（RT）对久坐的唐氏综合征成人的抗氧化防御系统的影响。通过不同的社区支持团体，共招募了 36 名唐氏综合征男性成年人。其中 18 名被随机分配到 6 个站点的循环 RT 程序中，每周 3 天，持续 12 周。评估了血浆总抗氧化状态（TAS）、还原型谷胱甘肽（GHS）、抗坏血酸、血清 -生育酚和红细胞谷胱甘肽还原酶活性。还评估了血浆丙二醛（MDA）和羰基（CG）作为氧化损伤的标志物。完成训练计划后，膝关节伸肌和屈肌的动态扭矩以及最大握力显著提高。血浆 TAS 和红细胞谷胱甘肽还原酶（GR）活性显著增加。相反，MDA 和 CG 水平显著降低。结论是，RT 改善了唐氏综合征成人的抗氧化防御系统并减少了氧化损伤。此外，还需要进行长期研究，以确定增加的抗氧化系统是否可以改善唐氏综合征成人的临床结局。
