理解Toll通路变化的路线图：与“β-抑制蛋白和SUMO蛋白酶Ulp1对Toll信号传导和炎症的调节”配套使用的教育入门指南
A roadmap to understanding toll pathway changes: an educational primer for use with "regulation of toll signaling and inflammation by β-arrestin and the SUMO protease Ulp1".
作者信息
Schmidt Rebecca L
机构信息
Department of Biology and Chemistry, Upper Iowa University, Fayette, Iowa 52142.
出版信息
Genetics. 2014 Apr;196(4):923-9. doi: 10.1534/genetics.114.162289.
Abstract
An article by Anjum et al. in the December 2013 issue of GENETICS can be used to illustrate reverse genetic manipulation in a model organism, targeted RNA interference, synergistic gene interaction, and biochemical regulation of gene expression using post-translational modification. This Primer provides background information, technical explanations of methods and genetic approaches from the study, an example approach for classroom use, and discussion questions to promote understanding of the research article.
摘要
安朱姆等人在2013年12月期《遗传学》上发表的一篇文章可用于说明模式生物中的反向遗传操作、靶向RNA干扰、协同基因相互作用以及利用翻译后修饰对基因表达进行的生化调控。本入门文章提供了背景信息、该研究中方法和遗传方法的技术解释、一种课堂使用的示例方法以及促进对该研究文章理解的讨论问题。
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Regulation of Toll signaling and inflammation by β-arrestin and the SUMO protease Ulp1.β-arrestin 和 SUMO 蛋白酶 Ulp1 对 Toll 信号转导和炎症的调节。
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