Nakamura H, Okazawa T, Nagase H, Yoshida M, Ariizumi M, Okada A
Department of Public Health, Kanazawa University School of Medicine, Japan.
Int Arch Occup Environ Health. 1996;68(2):115-9. doi: 10.1007/BF00381243.
Involvement of endothelium-derived relaxing factor (EDRF) or endothelium-derived constricting factor (EDCF) has been proposed as the pathophysiologic mechanism of vibration-induced white finger (VWF). Recent evidence that endothelin is a potent vasoconstrictor peptide indicates that it may play a role in vasoregulation during vibration exposure through the local actions of EDRF or EDCF. Therefore, we examined the effects of grasping (50 N) and hand-arm vibration (50 m/s2 rms, 120 Hz, x-axis) on digital blood flow (DBF) and on the level of plasma endothelin in seven healthy male office workers. Grasping decreased DBF without affecting endothelin, and vibration increased DBF with a simultaneous reduction in endothelin. The grasping-induced decrease in DBF seemed to be due to mechanical compression of the vessels. The negative correlation between DBF and endothelin during vibration exposure suggests that a reduction in release of endothelin from smooth muscle into the vessel cavity during vibration leads to vasodilatation, possibly attributable to the local axon reflex.
内皮源性舒张因子（EDRF）或内皮源性收缩因子（EDCF）的参与被认为是振动性白指（VWF）的病理生理机制。最近有证据表明内皮素是一种强效的血管收缩肽，这表明它可能通过EDRF或EDCF的局部作用在振动暴露期间的血管调节中发挥作用。因此，我们研究了七名健康男性办公室职员在进行50牛的握力和手臂振动（均方根值50米/秒²，120赫兹，x轴）时对指端血流量（DBF）和血浆内皮素水平的影响。握力降低了DBF，但不影响内皮素水平，而振动增加了DBF，同时内皮素水平降低。握力引起的DBF降低似乎是由于血管的机械性压迫。振动暴露期间DBF与内皮素之间的负相关表明，振动期间平滑肌内皮素释放到血管腔内的减少导致血管舒张，这可能归因于局部轴突反射。
