Babhadiashar Nima, Sotoudeh Masoud, Azizi Ebrahim, Bashiri Jafar, Didevar Reza, Malekzadeh Reza, Ghahremani Mohammad Hossein
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran, Iran.
Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. ; Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Pharm Res. 2014 Winter;13(1):313-8.
Various substances in cigarette smoke including nicotine have been shown to promote/induce cancer cell proliferation. Since cotinine has a longer half life and stability in the blood, it has become the preferred biomarker for cigarette smoking exposure. Seventy-three gastric cancer patients were included in this study. The tumor tissues were stained with H & E for pathological evaluation. The cotinine levels were measured in urine using a competitive ELISA. Tumors were 90% adenocarcinoma with 63% intestinal and 37% diffuse subtypes. Tumors were poorly (45.2%) or moderately differentiated (41.1%) and localized mainly (77%) in the upper part of stomach. The levels of cotinine were significantly different between smoker (283.83 ± 178.10 ng/mL) and non-smoker (39.28 ± 113.34 ng/mL) groups (p < 0.001). However, there is no-significant correlation between tumor characteristics and cotinine level in smoker patients. Cotinine level correlates with smoking in gastric patients, however, correlation with the tumor features has not been observed.
香烟烟雾中的各种物质（包括尼古丁）已被证明可促进/诱导癌细胞增殖。由于可替宁在血液中的半衰期更长且更稳定，它已成为吸烟暴露的首选生物标志物。本研究纳入了73例胃癌患者。肿瘤组织用苏木精和伊红染色进行病理评估。使用竞争性酶联免疫吸附测定法测量尿液中的可替宁水平。肿瘤90%为腺癌，其中63%为肠型，37%为弥漫型。肿瘤分化差（45.2%）或中等分化（41.1%），主要位于胃上部（77%）。吸烟者（283.83±178.10纳克/毫升）和非吸烟者（39.28±113.34纳克/毫升）组之间的可替宁水平有显著差异（p<0.001）。然而，吸烟患者的肿瘤特征与可替宁水平之间无显著相关性。胃癌患者中可替宁水平与吸烟相关，但未观察到与肿瘤特征的相关性。
