Giannubilo Stefano Raffaele, Tiano Luca, Ciavattini Andrea, Landi Beatrice, Carnevali Paola, Principi Federica, Littarru Gian Paolo, Mazzanti Laura
Department of Clinical Sciences, Polytechnic University of Marche , Ancona, Italy .
Antioxid Redox Signal. 2014 Oct 10;21(11):1582-6. doi: 10.1089/ars.2014.5936. Epub 2014 Jun 25.
Coenzyme Q10 (CoQ10 or ubiquinone) is an essential component of the mitochondrial electron transport chain and is also present in various cellular membranes and in plasma lipoproteins. Diabetes, cardiovascular, neurodegenerative, and preeclampsia diseases are all associated with an alteration of CoQ10 level or its redox status. During pregnancy, we note that the plasma content of CoQ10 is significantly higher than amniotic. In the fetal growth restriction group, amniotic total CoQ10 levels were significantly higher versus healthy, while the amniotic oxygen radical absorbing capacity level was significantly lower. A significant negative correlation was observed between amniotic total CoQ10 and birthweight. Our observation leads to the hypothesis that the amniotic midtrimester CoQ10 content may be a marker of subsequent obstetric complications.
辅酶Q10（CoQ10或泛醌）是线粒体电子传递链的重要组成部分，也存在于各种细胞膜和血浆脂蛋白中。糖尿病、心血管疾病、神经退行性疾病和先兆子痫都与辅酶Q10水平或其氧化还原状态的改变有关。在孕期，我们注意到辅酶Q10的血浆含量显著高于羊水。在胎儿生长受限组中，羊水总辅酶Q10水平显著高于健康组，而羊水氧自由基吸收能力水平显著较低。羊水总辅酶Q10与出生体重之间存在显著负相关。我们的观察结果提出了一个假设，即孕中期羊水中辅酶Q10的含量可能是随后产科并发症的一个标志物。
