The University of California, David Geffen School of Medicine, Department of Obstetrics and Gynecology , 10833 Le Conte Ave, Box 951740, Los Angeles, CA 90095-1740 , USA +1 310 206 3670 ;
Expert Opin Biol Ther. 2014 Jul;14(7):917-29. doi: 10.1517/14712598.2014.900538. Epub 2014 Apr 19.
Embryonic stem cells and induced pluripotent stem cells have emerged as the gold standard of pluripotent stem cells and the class of stem cell with the highest potential for contribution to regenerative and therapeutic application; however, their translational use is often impeded by teratoma formation, commonly associated with pluripotency. We discuss a population of nontumorigenic pluripotent stem cells, termed Multilineage Differentiating Stress Enduring (Muse) cells, which offer an innovative and exciting avenue of exploration for the potential treatment of various human diseases.
This review discusses the origin of Muse cells, describes in detail their various unique characteristics, and considers future avenues of their application and investigation with respect to what is currently known of adult pluripotent stem cells in scientific literature. We begin by defining cell potency, then discuss both mesenchymal and various reported populations of pluripotent stem cells, and finally delve into Muse cells and the characteristics that set them apart from their contemporaries.
Muse cells derived from adipose tissue (Muse-AT) are efficiently, routinely and painlessly isolated from human lipoaspirate material, exhibit tripoblastic differentiation both spontaneously and under media-specific induction, and do not form teratomas. We describe qualities specific to Muse-AT cells and their potential impact on the field of regenerative medicine and cell therapy.
胚胎干细胞和诱导多能干细胞已成为多能干细胞的金标准，也是最有可能应用于再生和治疗的干细胞类别；然而，它们的转化应用常常受到畸胎瘤形成的阻碍，畸胎瘤通常与多能性有关。我们讨论了一类非致瘤性多能干细胞，称为多系分化应激耐受（Muse）细胞，为探索治疗各种人类疾病的潜在方法提供了创新和令人兴奋的途径。
本综述讨论了 Muse 细胞的起源，详细描述了它们的各种独特特征，并考虑了它们在科学文献中关于成体多能干细胞的现有知识的未来应用和研究途径。我们首先定义细胞潜能，然后讨论间充质细胞和各种已报道的多能干细胞群体，最后深入探讨 Muse 细胞及其特征，这些特征使它们有别于同类细胞。
从脂肪组织（Muse-AT）中分离出来的 Muse 细胞很容易从人体脂肪抽吸物中常规、轻松地分离出来，在自发和特定培养基诱导下表现出三胚层分化，且不会形成畸胎瘤。我们描述了 Muse-AT 细胞的特定性质及其对再生医学和细胞治疗领域的潜在影响。
