Universidad Autónoma de Baja California, Tijuana, Baja California, Mexico. Facultad de Ciencias Químicas e Ingeniería. Calzada Universidad #14418, Universidad Autónoma de Baja California, Parque Industrial Internacional Tijuana, 22390 Tijuana, Baja California, Mexico.
J Pharm Pharm Sci. 2019;22(1):313-331. doi: 10.18433/jpps29674.
The electrospinning technique is a useful and versatile approach for conversion of polymeric solutions into continuous fibers, ranging from a few micrometers (10-100 μm) to the scale of nanometers (10- 100 nm) in diameters. This technique can be used in a vast number of polymers, in some cases after modifying them to the required properties. The high surface-to-volume ratio of the fibers can improve some processes like cell binding and proliferation, drug loading, and mass transfer processes. One of the most important and studied areas of electrospinning is in the drug delivery field, for the controlled release of active substances ranging from antibiotics and anticancer agents, to macromolecules such as proteins and DNA. The advantage of this method is that a wide variety of low solubility drugs can be loaded into the fibers to improve their bioavailability or to attain controlled release. This review presents an overview of the reported drugs loaded into electrospun polymeric nanofibers to be used as drug delivery systems. These drugs are classified by their applications in pharmacy.
静电纺丝技术是将聚合物溶液转化为连续纤维的一种有用且通用的方法，纤维的直径范围从几微米（10-100μm）到纳米级（10-100nm）。这种技术可以用于大量的聚合物，在某些情况下，需要对它们进行改性以达到所需的性能。纤维的高表面积与体积比可以改善细胞结合和增殖、药物负载以及传质等过程。静电纺丝最重要和研究最多的领域之一是在药物输送领域，用于控制释放各种活性物质，范围从抗生素和抗癌剂到蛋白质和 DNA 等大分子。这种方法的优点是可以将多种低溶解度的药物负载到纤维中，以提高其生物利用度或实现控制释放。本文综述了报道的负载到静电纺丝聚合物纳米纤维中的药物，这些药物被用作药物输送系统。这些药物根据其在药剂学中的应用进行分类。
