Bin/Amphiphysin/Rvs（BAR）家族成员可使细胞中的膜发生弯曲。

Suarez Allison, Ueno Tasuku, Huebner Robert, McCaffery J Michael, Inoue Takanari

Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, 113-0033, Japan.

Sci Rep. 2014 May 6;4:4693. doi: 10.1038/srep04693.

We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function relationship of intracellular organelles.

我们提供了直接证据，证明Bin/Amphiphysin/Rvs（BAR）家族成员能够改变完整细胞中细胞器的稳态膜结构。响应可诱导的BAR分子驱动蛋白，细胞器的膜曲率方向和程度会发生明显变化。这种快速可诱导系统可能提供了一种机制，借此能更好地理解细胞内细胞器的结构-功能关系。