Barua Chandana Choudhury, Begum Shameem Ara, Sarma Dilip Kumar, Pathak Debesh Chandra, Borah Rumi Saikia
Department of Pharmacology and Toxicology, College of Veterinary Science, Khanapara, Assam Agricultural University, Guwahati, Assam, India.
Department of Veterinary Microbiology, College of Veterinary Science, Khanapara, Assam Agricultural University, Guwahati, Assam, India.
J Basic Clin Pharm. 2012 Sep;3(4):341-5. doi: 10.4103/0976-0105.105336.
The methanol extract of Alternanthera brasiliana Kuntze (Family: Amaranthaceae) leaf was investigated for its wound healing effect by excision wound model (in vivo) in aged Sprague Dawley rats. In excision wound model, compared to the control group, percent contraction of wound was significantly (P < 0.01) higher in A. brasiliana-treated group (5% w/w ointment). The collagen, elastin, and hydroxyproline contents of the granulation tissue of A. brasiliana-treated group increased significantly (P < 0.01) compared to the control group, indicating better wound healing activity of the test plant. These findings were also confirmed by histopathological examination. The results suggested that methanol extract of A. brasiliana possesses significant wound healing potential in aged animal wound model.
采用切除伤口模型(体内),在老年斯普拉格-道利大鼠中研究了巴西莲子草(苋科)叶的甲醇提取物的伤口愈合作用。在切除伤口模型中,与对照组相比,巴西莲子草治疗组(5% w/w软膏)的伤口收缩百分比显著更高(P < 0.01)。与对照组相比,巴西莲子草治疗组肉芽组织的胶原蛋白、弹性蛋白和羟脯氨酸含量显著增加(P < 0.01),表明受试植物具有更好的伤口愈合活性。这些发现也通过组织病理学检查得到证实。结果表明,巴西莲子草的甲醇提取物在老年动物伤口模型中具有显著的伤口愈合潜力。