2006-2012 年中国上海细菌性胃肠病原体沙门氏菌和志贺氏菌的实验室监测。
Laboratory monitoring of bacterial gastroenteric pathogens Salmonella and Shigella in Shanghai, China 2006-2012.
机构信息
Department of Food Science and Technology, School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai,P.R. China.
Department of Nutrition and Food Science,University of Maryland,College Park, MD,USA.
出版信息
Epidemiol Infect. 2015 Feb;143(3):478-85. doi: 10.1017/S0950268814001162. Epub 2014 May 15.
In 2006 we initiated an enhanced laboratory-based surveillance of Salmonella and Shigella infections in Shanghai, China. A total of 4483 Salmonella and 2226 Shigella isolates were recovered from stool specimens by 2012. In 80 identified Salmonella serovars, Enteritidis (34·5%) and Typhimurium (26·2%) were the most common. Shigella (S.) sonnei accounted for 63·9% of human Shigella infections over the same time period, and replaced S. flexneri to become the primary cause of shigellosis since 2010. Overall, a high level of antimicrobial resistance was observed in Salmonella and Shigella, particularly to nalidixic acid, ampicillin, and tetracycline. Ciprofloxacin resistance was common in Salmonella Typhimurium (21·0%) and S. flexneri (37·6%). The cephalosporin resistance in both pathogens also increased over the years, ranging from 3·4% to 7·0% in Salmonella, and from 10·4% to 28·6% in Shigella. Resistance to multiple antimicrobials was also identified in a large number of the isolates. This study provides insight into the distribution of Salmonella and Shigella in diarrhoeal diseases.
2006 年，我们在中国上海启动了一项强化的基于实验室的沙门氏菌和志贺氏菌感染监测。到 2012 年，共从粪便标本中分离出 4483 株沙门氏菌和 2226 株志贺氏菌。在 80 种确定的沙门氏菌血清型中，肠炎沙门氏菌（34.5%）和鼠伤寒沙门氏菌（26.2%）最为常见。同时期，志贺氏菌（Shigella）感染中，宋内志贺菌（S. sonnei）占 63.9%，并于 2010 年取代福氏志贺菌（S. flexneri）成为志贺菌病的主要病原体。总体而言，沙门氏菌和志贺氏菌的耐药性水平较高，特别是对萘啶酸、氨苄西林和四环素。环丙沙星耐药在鼠伤寒沙门氏菌（21.0%）和福氏志贺菌（37.6%）中较为常见。这两种病原体的头孢菌素耐药性也逐年增加，沙门氏菌的耐药率从 3.4%至 7.0%，志贺氏菌的耐药率从 10.4%至 28.6%。大量分离株也表现出对多种抗菌药物的耐药性。本研究深入了解了腹泻病中沙门氏菌和志贺氏菌的分布情况。
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