Kemal Y, Demirağ G, Ekiz K, Yücel I
Department of Medical Oncology, Faculty of Medicine, 19 Mayıs University , Samsun , Turkey.
J Obstet Gynaecol. 2014 Aug;34(6):515-8. doi: 10.3109/01443615.2014.912620. Epub 2014 May 15.
New studies show that inflammatory markers and blood cells may be related to epithelial ovarian cancer (EOC). We aimed to examine whether mean platelet volume would be a useful marker for EOC patients to predict tumour burden and prognosis, and investigate the difference in MPV values between EOC patients and healthy controls. We retrospectively investigated 113 ovarian cancer patients who underwent surgery between January 2008 and July 2012 and 90 healthy subjects. MPV levels were significantly higher in preoperative EOC patients compared with healthy subjects (8.26 fl vs 7.71 fl; p = 0.004). Also NLR and PLR values were significantly higher in EOC patients (NLR, 3.48 vs 2.37; p = 0.000; PLR, 241 vs 148; p = 0.000). Surgical tumour resection resulted in a significant decrease in MPV levels (8.26 fl vs 7.61 fl; p = 0.001). NLR values also decreased after tumour resection significantly similar to CA125 (NLR, 3.48 vs 2.49; p = 0.000). Our data suggests that MPV could be a promising and easily available biomarker for monitoring EOC patients.
新的研究表明，炎症标志物和血细胞可能与上皮性卵巢癌（EOC）有关。我们旨在研究平均血小板体积是否可作为EOC患者预测肿瘤负荷和预后的有用标志物，并调查EOC患者与健康对照者之间MPV值的差异。我们回顾性研究了2008年1月至2012年7月期间接受手术的113例卵巢癌患者和90例健康受试者。术前EOC患者的MPV水平显著高于健康受试者（8.26 fl对7.71 fl；p = 0.004）。此外，EOC患者的NLR和PLR值也显著更高（NLR，3.48对2.37；p = 0.000；PLR，241对148；p = 0.000）。手术切除肿瘤后，MPV水平显著下降（8.26 fl对7.61 fl；p = 0.001）。肿瘤切除后NLR值也显著下降，与CA125相似（NLR，3.48对2.49；p = 0.000）。我们的数据表明，MPV可能是一种有前景且易于获得的用于监测EOC患者的生物标志物。
