Chocano-Bedoya Patricia O, Mirzaei Fariba, O'Reilly Eilis J, Lucas Michel, Okereke Olivia I, Hu Frank B, Rimm Eric B, Ascherio Alberto
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
J Affect Disord. 2014 Jul;163:25-32. doi: 10.1016/j.jad.2014.03.023. Epub 2014 Mar 27.
Despite an extensive literature on the role of inflammation and depression, few studies have evaluated the association between inflammatory biomarkers and depression in a prospective manner, and results are inconclusive.
We conducted a prospective analysis of blood levels of CRP, IL-6 and TNFα-R2 in 4756 women participating in the Nurses׳ Health Study who donated blood in 1990 and were depression-free up to 1996. Participants were followed between 1996 and 2008 for reports of clinical diagnosis depression or antidepressant use. Additionally, we conducted cross-sectional analyses for CRP, IL-6 and TNFα-R2 and antidepressant use at time of blood draw.
After adjustment for body mass index, menopause status, use of anti-inflammatory drugs and other covariates, no significant associations between CRP, IL-6 and TNFα-R2 and incident depression were observed after a follow-up of 6-18 years. However, menopause status appears to modify the association between IL-6 and depression risk. In cross-sectional analyses, TNFα-R2 was associated with antidepressant use (OR=1.96, 95% CI=1.23-3.13, P-trend=0.001), but no significant associations were found for CRP and IL-6.
Depression diagnosis was first assessed in 1996, 6 years after blood draw. However the biomarkers have high within-person correlations with measurements 4 years apart.
Blood levels of CRP, IL-6 and TNFα-R2 were not associated with incident depression over a follow-up of 6-18 years. In cross-sectional analyses, antidepressant use may be associated with higher levels of TNFα-R2 but no associations with depression or antidepressant use were observed in the prospective analysis.
尽管关于炎症与抑郁症之间的关系已有大量文献，但很少有研究以前瞻性的方式评估炎症生物标志物与抑郁症之间的关联，且结果尚无定论。
我们对参加护士健康研究的4756名女性的血液中CRP、IL-6和TNFα-R2水平进行了前瞻性分析，这些女性在1990年献血，截至1996年无抑郁症。在1996年至2008年期间对参与者进行随访，以获取临床诊断抑郁症或使用抗抑郁药的报告。此外，我们对采血时的CRP、IL-6和TNFα-R2以及抗抑郁药的使用情况进行了横断面分析。
在调整了体重指数、绝经状态、使用抗炎药物和其他协变量后，在6至18年的随访中，未观察到CRP、IL-6和TNFα-R2与新发抑郁症之间存在显著关联。然而，绝经状态似乎会改变IL-6与抑郁症风险之间的关联。在横断面分析中，TNFα-R2与抗抑郁药的使用相关（OR = 1.96，95% CI = 1.23 - 3.13，P趋势 = 0.001），但未发现CRP和IL-6有显著关联。
抑郁症诊断于采血6年后的1996年首次评估。然而，生物标志物在个体内与相隔4年的测量值具有高度相关性。
在6至18年的随访中，CRP、IL-6和TNFα-R2的血液水平与新发抑郁症无关。在横断面分析中，抗抑郁药的使用可能与较高水平的TNFα-R2相关，但在前瞻性分析中未观察到与抑郁症或抗抑郁药使用的关联。
