Piacentini Roberto, De Chiara Giovanna, Li Puma Domenica D, Ripoli Cristian, Marcocci Maria E, Garaci Enrico, Palamara Anna T, Grassi Claudio
Institute of Human Physiology, Medical School, Università Cattolica del Sacro Cuore Rome, Italy.
Institute of Translational Pharmacology, National Research Council Rome, Italy.
Front Pharmacol. 2014 May 7;5:97. doi: 10.3389/fphar.2014.00097. eCollection 2014.
Among the multiple factors concurring to Alzheimer's disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.
在导致阿尔茨海默病（AD）发病的多种因素中，应更加关注感染因子所起的作用。越来越多的流行病学和实验证据表明，复发性单纯疱疹病毒1型（HSV-1）感染是AD的一个风险因素，尽管其潜在的分子和功能机制尚未完全阐明。在此，我们回顾了表明HSV-1感染与AD有关的文献，并简要提及了这些发现可能的药理学意义。
