应对抗生素耐药性的另外八种方法。
Eight more ways to deal with antibiotic resistance.
作者信息
Metz Matthew, Shlaes David M
机构信息
U.S. Department of Health and Human Services, Biomedical Advanced Research and Development Authority, Broad Spectrum Antimicrobials Program, Washington, DC, USA
Anti-Infectives Consulting LLC, Stonington, Connecticut, USA.
出版信息
Antimicrob Agents Chemother. 2014 Aug;58(8):4253-6. doi: 10.1128/AAC.02623-14. Epub 2014 May 27.
Abstract
The fight against antibiotic resistance must be strengthened. We propose actions that U.S. government agencies and private sector entities can take to build a more comprehensive effort. These actions can increase the viability of investing in new antibiotics, ensure the quality and stewardship of all antibiotics, and make responses to emerging resistance more informed. Success requires the thoughtful exercise of federal authority and a firm commitment to share data and reward developers for the value generated with new, life-saving antibiotics.
摘要
必须加强对抗生素耐药性的斗争。我们提出了美国政府机构和私营部门实体可以采取的行动，以开展更全面的努力。这些行动可以提高投资开发新抗生素的可行性，确保所有抗生素的质量并合理使用，以及使对新出现的耐药性的应对更具依据。成功需要审慎运用联邦权力，并坚定承诺共享数据，以及奖励那些用新的、挽救生命的抗生素创造价值的开发者。
相似文献
1
Eight more ways to deal with antibiotic resistance.应对抗生素耐药性的另外八种方法。
Antimicrob Agents Chemother. 2014 Aug;58(8):4253-6. doi: 10.1128/AAC.02623-14. Epub 2014 May 27.
2
Simple solutions reflect misunderstanding of animal antibiotic use.简单的解决方案反映了对动物抗生素使用的误解。
Antimicrob Agents Chemother. 2015 Jan;59(1):750. doi: 10.1128/AAC.04451-14.
3
Reply to "Simple solutions reflect misunderstanding of animal antibiotic use".对《简单解决方案反映出对动物抗生素使用的误解》的回复
Antimicrob Agents Chemother. 2015 Jan;59(1):751. doi: 10.1128/AAC.04604-14.
4
FDA targets antibiotic use in livestock.美国食品药品监督管理局针对牲畜使用抗生素的情况采取行动。
JAMA. 2010 Jul 28;304(4):396. doi: 10.1001/jama.2010.1003.
5
Adjuncts and alternatives in the time of antibiotic resistance and in-feed antibiotic bans.抗生素耐药时代及饲料中抗生素禁令下的辅助手段与替代方案
Microb Biotechnol. 2017 Jul;10(4):674-677. doi: 10.1111/1751-7915.12730.
6
Antibiotics, animals, and people--again!抗生素、动物与人类——再谈！
Science. 2001 Jan 19;291(5503):397. doi: 10.1126/science.1058907.
7
Animal antibiotics under tougher United States scrutiny as consensus grows on "superbug" risk to humans.随着人们越来越认识到“超级细菌”对人类的风险，美国对动物用抗生素的审查日益严格。
CMAJ. 2010 Aug 10;182(11):E513-4. doi: 10.1503/cmaj.109-3310. Epub 2010 Jul 12.
8
[Development of antibiotic resistance in animals not receiving antibiotic therapy].未接受抗生素治疗的动物中抗生素耐药性的发展
C R Biol. 2024 Mar 29;346(S1):9-12. doi: 10.5802/crbiol.116.
9
Collaborative Antimicrobial Stewardship in the Health Department.卫生部门的协作抗菌药物管理。
Infect Dis Clin North Am. 2020 Mar;34(1):145-160. doi: 10.1016/j.idc.2019.10.002. Epub 2019 Dec 10.
10
Defining antibiotic effectiveness and resistance: how a private party may soon rule judgments over susceptibility testing.
BMJ. 2016 Jan 6;352:h6849. doi: 10.1136/bmj.h6849.
引用本文的文献
1
Macro- and micro-influencers of antimicrobial costs…What do stewardship programs need to know?抗菌药物成本的宏观和微观影响因素……管理计划需要了解什么？
Antimicrob Steward Healthc Epidemiol. 2025 Feb 26;5(1):e68. doi: 10.1017/ash.2025.38. eCollection 2025.
2
Liposome-Based Antibacterial Delivery: An Emergent Approach to Combat Bacterial Infections.基于脂质体的抗菌药物递送：对抗细菌感染的一种新兴方法。
ACS Omega. 2023 Sep 22;8(39):35442-35451. doi: 10.1021/acsomega.3c04893. eCollection 2023 Oct 3.
3
Recent Advances in Antimicrobial Nano-Drug Delivery Systems.抗菌纳米药物递送系统的最新进展
Nanomaterials (Basel). 2022 May 29;12(11):1855. doi: 10.3390/nano12111855.
4
Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance.脂质体作为抗生素递送系统：一种对抗抗生素耐药性的有前景的纳米技术策略。
Molecules. 2021 Apr 2;26(7):2047. doi: 10.3390/molecules26072047.
5
Antibiotics in Food Chain: The Consequences for Antibiotic Resistance.食物链中的抗生素：对抗生素耐药性的影响
Antibiotics (Basel). 2020 Oct 13;9(10):688. doi: 10.3390/antibiotics9100688.
6
Reducing the Bottleneck in Discovery of Novel Antibiotics.减少新型抗生素发现中的瓶颈。
Microb Ecol. 2017 Apr;73(3):658-667. doi: 10.1007/s00248-016-0889-3. Epub 2016 Nov 28.
7
Endless Resistance. Endless Antibiotics?无尽的耐药性。无尽的抗生素？
Medchemcomm. 2016 Jan 1;7(1):37-49. doi: 10.1039/C5MD00394F. Epub 2015 Nov 3.
8
Veterinary Medicine Needs New Green Antimicrobial Drugs.兽医学需要新型绿色抗菌药物。
Front Microbiol. 2016 Aug 3;7:1196. doi: 10.3389/fmicb.2016.01196. eCollection 2016.
9
Synthesis and antibacterial activity of novel 11-[3-[(arylcarbamoyl)oxy]propylamino]-11-deoxy-6-O-methyl-3-oxoerythromycin A 11-N,12-O-cyclic carbamate derivatives.新型11-[3-[(芳基氨基甲酰基)氧基]丙基氨基]-11-脱氧-6-O-甲基-3-氧代红霉素A 11-N,12-O-环氨基甲酸酯衍生物的合成及抗菌活性
J Antibiot (Tokyo). 2016 Nov;69(11):811-817. doi: 10.1038/ja.2016.42. Epub 2016 Apr 27.
10
Antibiotic treatment enhances the genome-wide mutation rate of target cells.抗生素治疗会提高靶细胞的全基因组突变率。
Proc Natl Acad Sci U S A. 2016 May 3;113(18):E2498-505. doi: 10.1073/pnas.1601208113. Epub 2016 Apr 18.
本文引用的文献
1
Distinguishable epidemics of multidrug-resistant Salmonella Typhimurium DT104 in different hosts.不同宿主中多重耐药鼠伤寒沙门氏菌 DT104 的明显流行。
Science. 2013 Sep 27;341(6153):1514-7. doi: 10.1126/science.1240578. Epub 2013 Sep 12.
2
Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC.全基因组测序鉴定出新型 mecA 同源物 mecC 的耐甲氧西林金黄色葡萄球菌分离株的人畜共患病传播。
EMBO Mol Med. 2013 Apr;5(4):509-15. doi: 10.1002/emmm.201202413. Epub 2013 Mar 25.
3
Extended-spectrum β-lactamase-producing Escherichia coli from retail chicken meat and humans: comparison of strains, plasmids, resistance genes, and virulence factors.零售鸡肉和人类中产超广谱β-内酰胺酶的大肠杆菌：菌株、质粒、耐药基因和毒力因子的比较。
Clin Infect Dis. 2013 Feb;56(4):478-87. doi: 10.1093/cid/cis929. Epub 2012 Dec 14.
4
The shared antibiotic resistome of soil bacteria and human pathogens.土壤细菌和人类病原体的共享抗生素耐药组。
Science. 2012 Aug 31;337(6098):1107-11. doi: 10.1126/science.1220761.
5
Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India.印度肺炎克雷伯菌 14 型携带新型金属β-内酰胺酶基因 bla(NDM-1)和新型红霉素酯酶基因的独特遗传结构特征。
Antimicrob Agents Chemother. 2009 Dec;53(12):5046-54. doi: 10.1128/AAC.00774-09. Epub 2009 Sep 21.
6
Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: implications for antibiotic stewardship.芝加哥一家教学医院中耐抗菌药物感染的医院及社会成本：对抗生素管理的启示
Clin Infect Dis. 2009 Oct 15;49(8):1175-84. doi: 10.1086/605630.
7
Multidrug resistance in bacteria.细菌中的多重耐药性
Annu Rev Biochem. 2009;78:119-46. doi: 10.1146/annurev.biochem.78.082907.145923.
8
Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection.金黄色葡萄球菌手术部位感染患者中耐甲氧西林所致的不良临床和经济后果。
Clin Infect Dis. 2003 Mar 1;36(5):592-8. doi: 10.1086/367653. Epub 2003 Feb 7.
Zotero 插件