Ghosh Rita, De Mrinmoy
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, Karnataka, India.
ACS Omega. 2023 Sep 22;8(39):35442-35451. doi: 10.1021/acsomega.3c04893. eCollection 2023 Oct 3.
The continued emergence and spread of drug-resistant pathogens and the decline in the approval of new antimicrobial drugs pose a major threat to managing infectious diseases, resulting in high morbidity and mortality. Even though a significant variety of antibiotics can effectively cure many bacterial infectious diseases, microbial infections remain one of the biggest global health problems, which may be due to the traditional drug delivery system's shortcomings which lead to poor therapeutic index, low drug absorption, and numerous other drawbacks. Further, the use of traditional antibiotics to treat infectious diseases has always been accompanied by the emergence of multidrug resistance and adverse side effects. Despite developing numerous new antibiotics, nanomaterials, and various techniques to combat infectious diseases, they have persisted as major global health issues. Improving the current antibiotic delivery systems is a promising approach to solving many life-threatening infections. In this context, nanoliposomal systems have recently attracted much attention. Herein, we attempt to provide a concise summary of recent studies that have used liposomal nanoparticles as delivery systems for antibacterial medicines. The minireview also highlights the enormous potential of liposomal nanoparticles as antibiotic delivery systems. The future of these promising approaches lies in developing more efficient delivery systems by precisely targeting bacterial cells with antibiotics with minimum cytotoxicity and high bacterial combating efficacy.
耐药病原体的持续出现和传播以及新型抗菌药物获批数量的减少，对传染病的管理构成了重大威胁，导致高发病率和高死亡率。尽管种类繁多的抗生素能够有效治愈许多细菌感染性疾病，但微生物感染仍然是全球最大的健康问题之一，这可能是由于传统给药系统存在缺陷，导致治疗指数不佳、药物吸收低以及许多其他缺点。此外，使用传统抗生素治疗传染病一直伴随着多重耐药性和副作用的出现。尽管已经开发出许多新型抗生素、纳米材料和各种对抗传染病的技术，但这些问题仍然是全球主要的健康问题。改进当前的抗生素给药系统是解决许多危及生命的感染的一种有前景的方法。在这种背景下，纳米脂质体系统最近受到了广泛关注。在此，我们试图简要总结最近使用脂质体纳米颗粒作为抗菌药物递送系统的研究。这篇综述还强调了脂质体纳米颗粒作为抗生素递送系统的巨大潜力。这些有前景的方法的未来在于开发更高效的递送系统，通过以最小的细胞毒性和高抗菌效力精确地将抗生素靶向细菌细胞。
