Division of Clinical Infectious Diseases, Medical Clinic, Research Center Borstel, Borstel, Germany, and Department of Medicine, University of Namibia School of Medicine, Windhoek, Namibia
Clin Med (Lond). 2014 Jun;14(3):279-85. doi: 10.7861/clinmedicine.14-3-279.
Multidrug-resistant and extensively drug-resistant tuberculosis are recent global health issues, which makes tuberculosis - after the success of short course treatment during the second half of the last century - a major health challenge. Globalisation, health inequalities, competing economic interests and political instability contribute substantially to the spread of drug-resistant strains, which are associated with high rates of morbidity and mortality. Issues such as increasing transmission of drug-resistant strains, poor diagnostic coverage and a lengthy, toxic treatment need to be overcome by innovative approaches to tuberculosis control, prevention, diagnostics and treatment. This review addresses recent developments and future concepts.
耐多药和广泛耐药结核病是最近出现的全球卫生问题，使得结核病成为继上世纪后半叶成功实施短程化疗之后的一个主要卫生挑战。全球化、卫生不平等、相互竞争的经济利益和政治不稳定极大地助长了耐药菌株的传播，这些菌株与高发病率和死亡率相关。耐药菌株传播增加、诊断覆盖面差以及治疗过程漫长且毒性大等问题，需要通过创新方法来控制结核病、预防结核病、诊断结核病和治疗结核病。本综述讨论了最近的发展和未来的概念。
