Sobhani-Nasab Ali, Banafshe Hamid Reza, Atapour Amir, Khaksary Mahabady Mahmood, Akbari Maryam, Daraei Abdolreza, Mansoori Yaser, Moradi Hasan-Abad Amin
Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Front Med Technol. 2024 Jan 23;5:1330007. doi: 10.3389/fmedt.2023.1330007. eCollection 2023.
The emergence of nanotechnology as a field of study can be traced back to the 1980s, at which point the means to artificially produce, control, and observe matter on a nanometer level was made viable. Recent advancements in technology have enabled us to extend our reach to the nanoscale, which has presented an unparalleled opportunity to directly target biomolecular interactions. As a result of these developments, there is a drive to arise intelligent nanostructures capable of overcoming the obstacles that have impeded the progress of conventional pharmacological methodologies. After four decades, the gradual amalgamation of bio- and nanotechnologies is initiating a revolution in the realm of disease detection, treatment, and monitoring, as well as unsolved medical predicaments. Although a significant portion of research in the field is still confined to laboratories, the initial application of nanotechnology as treatments, vaccines, pharmaceuticals, and diagnostic equipment has now obtained endorsement for commercialization and clinical practice. The current issue presents an overview of the latest progress in nanomedical strategies towards alleviating antibiotic resistance, diagnosing and treating cancer, addressing neurodegenerative disorders, and an array of applications, encompassing dentistry and tuberculosis treatment. The current investigation also scrutinizes the deployment of sophisticated smart nanostructured materials in fields of application such as regenerative medicine, as well as the management of targeted and sustained release of pharmaceuticals and therapeutic interventions. The aforementioned concept exhibits the potential for revolutionary advancements within the field of immunotherapy, as it introduces the utilization of implanted vaccine technology to consistently regulate and augment immune functions. Concurrently with the endeavor to attain the advantages of nanomedical intervention, it is essential to enhance the unceasing emphasis on nanotoxicological research and the regulation of nanomedications' safety. This initiative is crucial in achieving the advancement in medicine that currently lies within our reach.
纳米技术作为一个研究领域的出现可以追溯到20世纪80年代，那时人工生产、控制和观察纳米级物质的手段变得可行。最近的技术进步使我们能够将触角延伸到纳米尺度，这为直接靶向生物分子相互作用提供了前所未有的机会。由于这些发展，人们有动力去开发能够克服阻碍传统药理学方法进展的障碍的智能纳米结构。经过四十年，生物和纳米技术的逐渐融合正在引发疾病检测、治疗和监测领域以及未解决的医学难题方面的一场革命。尽管该领域的大部分研究仍局限于实验室，但纳米技术作为治疗方法、疫苗、药物和诊断设备的初步应用现已获得商业化和临床实践的认可。本期概述了纳米医学策略在缓解抗生素耐药性、诊断和治疗癌症、解决神经退行性疾病以及一系列应用（包括牙科和结核病治疗）方面的最新进展。当前的研究还审视了复杂的智能纳米结构材料在再生医学等应用领域的部署，以及药物和治疗干预的靶向和持续释放管理。上述概念在免疫治疗领域展现出了革命性进展的潜力，因为它引入了植入疫苗技术的应用，以持续调节和增强免疫功能。在努力实现纳米医学干预优势的同时，必须不断加强对纳米毒理学研究和纳米药物安全性监管的重视。这一举措对于实现目前我们力所能及的医学进步至关重要。
