Celá Petra, Veselá Barbora, Matalová Eva, Večeřa Zbyněk, Buchtová Marcela
Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
Cells Tissues Organs. 2014;199(1):1-23. doi: 10.1159/000362163. Epub 2014 Jun 4.
Applications of nanoparticles (NP) in medicine, industry and other branches of human activities undoubtedly contribute to technology development and well-being. However, as NP are very small units in a wide range of materials, there is a lack of information related to possible side effects potentially affecting the health of organisms. There is increasing experimental interest in the determination of environmental effects on humans exposed to NP. Most such experimental studies focus on adult populations or adult experimental animals. However, embryos can be more sensitive to pollutants and environmental impacts in some species. Therefore, some investigations dealing particularly with the effects of NP on embryonic development have appeared recently and this issue is becoming of great concern. The aim of this review is to summarize the knowledge on the effects of various nanomaterials on embryonic development. A comprehensive collection of significant experimental nanotoxicity data is presented, which also indicate how the toxic effect of NP can be mediated and modulated with respect to possible effective protection strategies.
纳米颗粒（NP）在医学、工业及人类活动的其他领域的应用无疑推动了技术发展并增进了福祉。然而，由于纳米颗粒是广泛材料中的非常小的单元，缺乏与可能影响生物体健康的潜在副作用相关的信息。对于确定纳米颗粒对人类的环境影响，实验兴趣日益浓厚。大多数此类实验研究集中于成年人群或成年实验动物。然而，在某些物种中，胚胎可能对污染物和环境影响更为敏感。因此，最近出现了一些特别针对纳米颗粒对胚胎发育影响的研究，这个问题正变得备受关注。本综述的目的是总结关于各种纳米材料对胚胎发育影响的知识。文中呈现了大量重要的实验纳米毒性数据，这些数据还表明了纳米颗粒的毒性作用如何能够通过可能的有效保护策略得到介导和调节。
