在意大利鉴定出一株产新德里金属β-内酰胺酶-4（NDM-4）的大肠杆菌。
Identification of a New Delhi metallo-β-lactamase-4 (NDM-4)-producing Escherichia coli in Italy.
作者信息
Coppo Erika, Del Bono Valerio, Ventura Francesco, Camera Marco, Orengo Giovanni, Viscoli Claudio, Marchese Anna
机构信息
Microbiology Unit DISC, University of Genoa, IRCCS AOU San Martino-IST, Largo R, Benzi 10, 16132 Genoa, Italy.
出版信息
BMC Microbiol. 2014 Jun 7;14:148. doi: 10.1186/1471-2180-14-148.
BACKGROUND
During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with blaNDM-4 gene were investigated.
RESULTS
The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and β-lactams. The strains produced the NDM-4 carbapenemase and the blaNDM-4 gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405).
CONCLUSIONS
This is the first report on the emergence of an MDR strain of E.coli producing the NDM-4 MBL in Italy.
背景
2012年6月至7月期间，从意大利热那亚一家大型三级护理医院一个病房住院的两名患者身上分离出6株耐亚胺培南大肠杆菌。对与blaNDM - 4基因相关的遗传特征进行了调查。
结果
这些分离株表现出相同的脉冲场凝胶电泳（PFGE）图谱以及对氨基糖苷类、氟喹诺酮类和β-内酰胺类的多重耐药（MDR）表型。这些菌株产生NDM - 4碳青霉烯酶，且blaNDM - 4基因是1类整合子可变区的一部分。多位点序列分型（MLST）分析表明，所有分离株均属于序列型405（ST405）。
结论
这是意大利首次关于产生NDM - 4金属β-内酰胺酶的大肠杆菌多重耐药菌株出现的报道。
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