Yu Bo-Yi, Zheng Jie, Chang Yung, Sin Mei-Chan, Chang Chih-Hung, Higuchi Akon, Sun Yi-Ming
R&D Center for Membrane Technology and Department of Chemical Engineering Chung Yuan Christian University , Chung-Li, Taoyuan 320, Taiwan.
Langmuir. 2014 Jul 1;30(25):7502-12. doi: 10.1021/la500917s. Epub 2014 Jun 19.
Surface coating of antifouling materials on the substrates offers convenient strategies and great opportunities to improve their biocompatibility and functions of host substrates for wide biomedical applications. In this work, we present a general surface zwitterionization strategy to improve surface biocompatibility and antifouling properties of titanium (Ti) by grafting zwitterionic poly(sulfobetaine methacrylate) (polySBMA). This method also demonstrates its general applicability to graft polySBMA onto Ti surface using different anchoring agents of dopamine and silane. The resulting polySBMA grafted from dopamine- (pTi-D-pSBMA) and silane-anchored titanium surfaces (pTi-Si-pSBMA) surfaces exhibit superlow fouling ability to highly resist the adhesions of plasma proteins, platelets, erythrocytes, leukocytes, human fibroblast (HT1080), E. coli, and S. epidermidis. The interfacial properties of the surface-modified Ti surfaces are analyzed and correlated with their antifouling properties. The new method and materials provide a more general, flexible, and robust way to produce an excellent nonfouling surface with adjustable interfacial structures of grafted polymers, which hopefully can be expanded to wider applications based on both the structure and surface superiorities.
在基底上涂覆防污材料为改善其生物相容性以及宿主基底在广泛生物医学应用中的功能提供了便捷策略和巨大机遇。在本工作中，我们提出了一种通用的表面两性离子化策略，通过接枝两性离子型聚（甲基丙烯酰基磺酸甜菜碱）（聚SBMA）来改善钛（Ti）的表面生物相容性和防污性能。该方法还证明了使用多巴胺和硅烷等不同锚定剂将聚SBMA接枝到Ti表面的通用性。从多巴胺锚定的钛表面（pTi-D-pSBMA）和硅烷锚定的钛表面（pTi-Si-pSBMA）接枝得到的聚SBMA表面对血浆蛋白、血小板、红细胞、白细胞、人成纤维细胞（HT1080）、大肠杆菌和表皮葡萄球菌的粘附具有超低的污垢形成能力，能高度抵抗其粘附。分析了表面改性Ti表面的界面性质，并将其与防污性能相关联。这种新方法和材料提供了一种更通用、灵活且稳健的方式来制备具有可调节接枝聚合物界面结构的优异无污表面，有望基于结构和表面优势将其扩展到更广泛的应用中。
