Julius Kühn-Institut - Federal Research Centre for Cultivated Plants (JKI), Institute for Epidemiology and Pathogen Diagnostics, Messeweg 11-12, 38104 Braunschweig, Germany.
Institute of Crop Science and Resource Conservation - Soil Science and Soil Ecology, University of Bonn, Nussallee 13, 53115 Bonn, Germany.
Trends Microbiol. 2014 Sep;22(9):536-45. doi: 10.1016/j.tim.2014.05.005. Epub 2014 Jun 17.
Large amounts of veterinary antibiotics are applied worldwide to farm animals and reach agricultural fields by manure fertilization, where they might lead to an increased abundance and transferability of antibiotic-resistance determinants. In this review we discuss recent advances, limitations, and research needs in determining the fate of veterinary antibiotics and resistant bacteria applied with manure to soil, and their effects on the structure and function of soil microbial communities in bulk soils and the rhizosphere. The increased abundance and mobilization of antibiotic-resistance genes (ARGs) might contribute to the emergence of multi-resistant human pathogens that increasingly threaten the successful antibiotic treatment of bacterial infections.
大量的兽用抗生素被应用于全世界的农场动物，并通过粪便施肥进入农业领域，在那里它们可能导致抗生素抗性决定因素的丰度和可转移性增加。在这篇综述中，我们讨论了在确定兽用抗生素和与粪便一起施用于土壤的耐药细菌的命运，及其对土壤微生物群落的结构和功能的影响方面的最新进展、局限性和研究需求。抗生素抗性基因（ARGs）的丰度增加和移动性增加可能有助于多耐药人类病原体的出现，这些病原体越来越威胁到细菌感染的成功抗生素治疗。
