Barker D J, Osmond C, Golding J, Kuh D, Wadsworth M E
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital.
BMJ. 1989 Mar 4;298(6673):564-7. doi: 10.1136/bmj.298.6673.564.
In national samples of 9921 10 year olds and 3259 adults in Britain systolic blood pressure was inversely related to birth weight. The association was independent of gestational age and may therefore be attributed to reduced fetal growth. This suggests that the intrauterine environment influences blood pressure during adult life. It is further evidence that the geographical differences in average blood pressure and mortality from cardiovascular disease in Britain partly reflect past differences in the intrauterine environment. Within England and Wales 10 year olds living in areas with high cardiovascular mortality were shorter and had higher resting pulse rates than those living in other areas. Their mothers were also shorter and had higher diastolic blood pressures. This suggests that there are persisting geographical differences in the childhood environment that predispose to differences in cardiovascular mortality.
在英国对9921名10岁儿童和3259名成年人的全国性抽样调查中，收缩压与出生体重呈负相关。这种关联独立于胎龄，因此可能归因于胎儿生长受限。这表明子宫内环境会影响成年后的血压。这进一步证明，英国平均血压和心血管疾病死亡率的地理差异部分反映了过去子宫内环境的差异。在英格兰和威尔士，生活在心血管疾病死亡率高的地区的10岁儿童比生活在其他地区的儿童更矮，静息心率更高。他们的母亲也更矮，舒张压更高。这表明儿童时期的环境存在持续的地理差异，这些差异易导致心血管疾病死亡率的差异。
